The Indian Journal of Pediatrics

, Volume 81, Issue 4, pp 394–396

Recurrent Oral Thrush

  • Somu Sivabalan
  • Shriraam Mahadevan
  • M. V. Srinath
Clinical Brief

DOI: 10.1007/s12098-013-1201-x

Cite this article as:
Sivabalan, S., Mahadevan, S. & Srinath, M.V. Indian J Pediatr (2014) 81: 394. doi:10.1007/s12098-013-1201-x


Autoimmune polyendocrinopathy syndrome type 1 (APS-1) is characterized by the presence of at least two out of three clinical features, which include chronic mucocutaneous candidiasis (CMC), Addison’s disease and hypoparathyroidism. The authors’ present an one and a half year old girl with recurrent oral thrush who presented with generalised afebrile seizure. Evaluation revealed severe hypocalcemia with low parathormone and normal vitamin D level consistent with hypoparathyroidism. In view of the oral candidiasis and hypoparathyroidism, a clinical possibility of autoimmune polyglandular syndrome (type 1) was strongly considered. Her mother, on subsequent pregnancy was subjected to gene analysis of the fetus (chorionic villus sampling) and also for this child (index case). Both the fetus and index child were confirmed to have the AIRE gene mutation of APS1. After detailed counseling the parents opted for medical termination of the pregnancy. In children who present with recurrent oral thrush we need to consider but also look beyond immunodeficiency.


Polyglandular autoimmune syndrome Autoimmune polyendocrinopathy syndrome type 1 APS-1 Whitaker’s syndrome Chronic mucocutaneous candidiasis Addison’s disease Hypoparathyroidism Hypocalcemic seizures 



Autoimmune polyendocrinopathy syndrome


Autoimmune regulator


Chronic mucocutaneous candidiasis

Copyright information

© Dr. K C Chaudhuri Foundation 2013

Authors and Affiliations

  • Somu Sivabalan
    • 1
  • Shriraam Mahadevan
    • 2
  • M. V. Srinath
    • 3
  1. 1.Department of Pediatric Pulmonology, Sundaram Medical FoundationDr Rangarajan Memorial HospitalChennaiIndia
  2. 2.Department of Endocrinology, Sundaram Medical FoundationDr Rangarajan Memorial HospitalChennaiIndia
  3. 3.Department of Pediatrics, Sundaram Medical FoundationDr Rangarajan Memorial HospitalChennaiIndia

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