Prevalence and Risk Factors for Hepatitis C Virus, Hepatitis B Virus, and Human Immunodeficiency Virus in Transfused Children in Kinshasa
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To determine seroprevalence of hepatitis C virus (HCV), human immunodeficiency virus (HIV), and hepatitis B virus (HBV) and associated factors among transfused children.
A multicenter cross-sectional study of transfused children aged between 18 mo and 13 y old was conducted in 4 hospitals in Kinshasa. Blood samples were collected for the detection of Hepatitis B surface antigen (HBsAg) and antibodies to HCV, HIV 1and 2.
A total of 177 (47.7 %) boys and 194 (52.3 %) girls participated in the study. The median age was 59.5 mo (Interquartile range IQR = 60.6). The prevalence rates of HCV, HBV, and HIV infection were 13.5 %, 1.6 %, and 1.3 %, respectively. Frequency of transfusion events were significantly associated with HCV (p < 0.001) and HIV (p < 0.05) infections.
HCV infection was by far more frequently identified than HBV and HIV infections among Congolese transfused children. Frequency of transfusion events was the only significant risk factor associated with HCV and HIV infections but not for HBV.
- Dhingra N, Hafner V. Safety of blood transfusion at the international level: the role of WHO. Transfus Clin Biol. 2006;13:200–2. CrossRef
- Cunha L, Plouzeau C, Ingrand P, et al. Use of replacement blood donors to study the epidemiology of major blood-borne viruses in the general population of Maputo, Mozambique. J Med Virol. 2007;79:1832–40. CrossRef
- Tapko J, Sam O, Diarra-Nama A. Status of blood safety in the WHO African region: report of the 2004 survey. 2007
- Bates I, Manyasi G, Medina Lara A. Reducing replacement donors in Sub-Saharan Africa: challenges and affordability. Transfus Med. 2007;17:434–42. CrossRef
- Marcucci C, Madjdpour C, Spahn DR. Allogeneic blood transfusions: benefit, risks and clinical indications in countries with a low or high human development index. Br Med Bull. 2004;70:15–28. CrossRef
- Allain JP. Transfusion risks of yesterday and of today. Transfus Clin Biol. 2003;10:1–5. CrossRef
- Ocak S, Kaya H, Cetin M, Ozturk M. Seroprevalence of hepatitis B and hepatitis C in patients with thalassemia and sickle cell anemia in a long-term follow-up. Arch Med Res. 2006;37:895–8. CrossRef
- Covas DT, Boturao Neto E, Zago MA. The frequency of blood-born viral infections in a population of polytransfused Brazilian patients. Rev Inst Med Trop Sao Paulo. 1993;35:271–3. CrossRef
- Schmunis GA, Cruz JR. Safety of the blood supply in Latin America. Clin Microbiol Rev. 2005;18:12–29. CrossRef
- Schmunis GA, Zicker F, Pinheiro F, Brandling-Bennett D. Risk for transfusion-transmitted infectious diseases in Central and South America. Emerg Infect Dis. 1998;4:5–11. CrossRef
- Tshilolo LM, Mukendi RK, Wembonyama SO. Blood transfusion rate in Congolese patients with sickle cell anemia. Indian J Pediatr. 2007;74:735–8. CrossRef
- Shaffer N, Hedberg K, Davachi F, et al. Trends and risk factors for HIV-1 seropositivity among outpatient children, Kinshasa, Zaire. AIDS. 1990;4:1231–6. CrossRef
- Bloch EM, Vermeulen M, Murphy E. Blood transfusion safety in Africa: a literature review of infectious disease and organizational challenges. Transfus Med Rev. 2012;26:164–80. CrossRef
- Calderón GM, González-Velázquez F, González-Bonilla CR, et al. Prevalence and risk factors of hepatitis C virus, hepatitis B virus, and human immunodeficiency virus in multiply transfused recipients in Mexico. Transfusion. 2009;49:2200–7. CrossRef
- Moore A, Herrera G, Nyamongo J, et al. Estimated risk of HIV transmission by blood transfusion in Kenya. Lancet. 2001;358:657–60. CrossRef
- Ministry of Plan. Enquete Demographique et de santé EDS-RDC 2007. Democratic Republic of Congo. Final report, Kinshasa. 2008.
- Programme National Multisectoriel de Lutte contre le SIDA (PNMLS). Rapport National de suivi de la declaration d’engagement UNGASS, Kinshasa. 2010.
- HIV infection diagnostic strategy by WHO, National AIDS program (PNLS). 2007.
- Candotti D, Allain J-P. Transfusion-transmitted hepatitis B virus infection. J Hepatol. 2009;551:798–809. CrossRef
- Prevalence and Risk Factors for Hepatitis C Virus, Hepatitis B Virus, and Human Immunodeficiency Virus in Transfused Children in Kinshasa
The Indian Journal of Pediatrics
Volume 80, Issue 8 , pp 659-662
- Cover Date
- Print ISSN
- Online ISSN
- Springer India
- Additional Links
- Hepatitis C virus
- Human immunodeficiency virus
- Hepatitis B virus
- Industry Sectors
- Author Affiliations
- 1. Department of Pediatrics, University of Kinshasa School of Medicine, Kinshasa, Japan
- 2. School of Public Health, University of Kinshasa School of Medicine, Kinshasa, Japan
- 3. Department of Blood Transfusion and Transplantation Immunology, Fukushima Medical University School of Medicine, Fukushima, Japan
- 6. Department of Transfusion Medicine and Transplantation Immunology, School of Medicine, Fukushima Medical University, Hikariga-oka, Fukushima City, Fukushima, 960-1295, Japan
- 4. Department of Environmental and Preventive Medicine, Shimane University, Shimane, Japan
- 5. Blood Transfusion National Program, Fukushima, Japan