The Indian Journal of Pediatrics

, Volume 80, Issue 4, pp 292–296

Antioxidant Levels at Diagnosis in Childhood Acute Lymphoblastic Leukemia

  • Nita Radhakrishnan
  • Veronique Dinand
  • Spriha Rao
  • Priyanka Gupta
  • G. S. Toteja
  • Manas Kalra
  • Satya Prakash Yadav
  • Anupam Sachdeva
Original Article

DOI: 10.1007/s12098-012-0892-8

Cite this article as:
Radhakrishnan, N., Dinand, V., Rao, S. et al. Indian J Pediatr (2013) 80: 292. doi:10.1007/s12098-012-0892-8

Abstract

Objective

To measure serum zinc, selenium, retinol and tocoferol levels at diagnosis of pediatric acute lymphoblastic leukemia (ALL) and to compare it to that of a control population. Correlation was made with episodes of febrile neutropenia during the first 8 wk of therapy.

Methods

Fasting levels of serum zinc, selenium, retinol and tocoferol were measured in 45 children diagnosed with acute lymphoblastic leukemia and in 20 healthy controls.

Results

Lower levels of baseline selenium and tocoferol were noted in patients who developed febrile neutropenia compared to the patients who did not (p = 0.022 and 0.026 respectively). Serum retinol was also lower in patients who developed sepsis when compared to those who did not.

Conclusions

Supplementation of antioxidants may be considered in clinical trials aiming at reducing infection related morbidity and mortality.

Keywords

ZinzSeleniumRetinolTocopherolAntioxidantsFebrile neutropeniaPediatric acute lymphoblastic leukemia

Copyright information

© Dr. K C Chaudhuri Foundation 2012

Authors and Affiliations

  • Nita Radhakrishnan
    • 1
  • Veronique Dinand
    • 1
  • Spriha Rao
    • 2
  • Priyanka Gupta
    • 2
  • G. S. Toteja
    • 2
  • Manas Kalra
    • 1
  • Satya Prakash Yadav
    • 1
  • Anupam Sachdeva
    • 1
  1. 1.Pediatric Hematology Oncology and BMT UnitInstitute for Child Health, Sir Ganga Ram HospitalNew DelhiIndia
  2. 2.Centre for Promotion of Nutrition Research and Training with special focus on North East, Tribal and Inaccessible population (Indian Council of Medical Research)New DelhiIndia