Fevers and the Rheumatologist Authors
Symposium on Pediatric Rheumatology-II
First Online: 16 October 2010 Received: 22 June 2010 Accepted: 06 July 2010 DOI:
Cite this article as: Manners, P.J. & Guttinger, R. Indian J Pediatr (2010) 77: 1173. doi:10.1007/s12098-010-0206-y Abstract
Fevers in children are mainly due to infection, malignancy or inflammatory conditions. Rheumatologists have an important role in the care of inflammatory conditions, many of which are associated with fevers. Seven conditions, the hereditary recurrent fever syndromes, have been defined with the presenting symptom of recurring fever, and for which mutation of a single gene has been defined: Chronic infantile neurological articular syndrome (CINCA), Familial cold autoinflammatory syndrome (FACS), Familial Mediterranean fever (FMF), hyperimmunoglobulinemia D (HIDS), Muckle-Wells syndrome (MWS), Pyogenic sterile arthritis and Pyoderma gangrenosum (PAPA) and Tumour necrosis factor receptor-associated periodic syndrome (TRAPS) . These conditions will be discussed in detail in regard to how they fit into the wider picture of pediatric rheumatological conditions, how the diagnoses may be established and the current recommended treatments for each condition.
Keywords Hereditary recurrent fever syndromes Cryopyrinopathies Abbreviations CINCA syndrome
Chronic Infantile Neurological Articular Syndrome
Familial Cold Autoinflammatory Syndrome
Familial Mediterranean Fever
Hyperimmunoglobulinemia D Syndrome
Neonatal-Onset Multi-System Inflammatory Disease
Pyogenic Sterile Arthritis, Pyoderma Gangrenosum and Acne
Periodic Fever, Aphthous Ulcers, Pharyngitis and Cervical Adenitis
Tumour Necrosis Factor Receptor-Associated Periodic Syndrome
Systemic Lupus Erythematosus
Juvenile Idiopathic Arthritis
Mixed Connective Tissue Disease
The authors certify that the article is original, is not under consideration by any other journal and has not been previously published. There has been no funding, no competing interests. The work is the authors’ own.
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