Original Article

The Indian Journal of Pediatrics

, Volume 77, Issue 12, pp 1387-1391

Childhood Pneumococcal Diseases and Serotypes: Can Vaccines Protect?

  • Kam Lun HonAffiliated withDepartment of Pediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong Email author 
  • , Margaret IpAffiliated withDepartment of Microbiology, Prince of Wales Hospital, The Chinese University of Hong Kong
  • , Kenneth LeeAffiliated withDepartment of Pharmacy, Prince of Wales Hospital, The Chinese University of Hong Kong
  • , Edmund Anthony NelsonAffiliated withDepartment of Pediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong
  • , Ka Ho Eric SheaAffiliated withPrince of Wales Hospital, The Chinese University of Hong Kong
  • , Yiu Sang Tony YuenAffiliated withPrince of Wales Hospital, The Chinese University of Hong Kong
  • , Ting Fan LeungAffiliated withDepartment of Pediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong

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Abstract

Objectives

To describe pneumococcal diseases in pediatric intensive care unit (PICU) and non-PICU patients.

Methods

The clinical, serotypes, and antibacterial sensitivity patterns of all children admitted to the pediatric wards (including PICU) of a university-affiliated teaching hospital from 2007 through 2009 with pneumococcal isolates were reviewed.

Results

Twelve cases of pneumococcal disease in children from 2007 through 2009 were reported. Five patients were admitted to PICU and 7 were general pediatric admissions. Four patients (2 PICU and 2 general pediatric) had received full or partial 7-valent pneumococcal vaccinations. All four patients recovered following systemic antibiotic treatment without sequelae. The serotypes of all PICU and some general pediatric cases were available and included 3, 6B, 19A and 19F. All isolates were sensitive to vancomycin. 50% were intermediate resistant/resistant to penicillin and 17% resistant to cefotaxime. PICU cases required longer total hospital stay (23 days vs 5 days, p = 0.013). Three patients were ventilated and one received inotropic support. There was no death in this series.

Conclusions

Pneumococcal disease may develop despite prior vaccination. The expanded coverage of newer polyvalent pneumococcal vaccines might have prevented some, but not all, of these admissions.

Keywords

Invasive S pneumoniae, Septicemia Antibiotic resistance