The Indian Journal of Pediatrics

, Volume 76, Issue 3, pp 309–312

Red baby syndrome a new disease due to parvovirus B-19 observed in Kerala

  • C. K. Sasidharan
  • P. Sugathan
  • Neena Mampilly
  • Ramesh Agarwal
  • Shashi Khare
  • Shiv Lal
  • C. K. Jayaram Paniker
Research Commentary

DOI: 10.1007/s12098-009-0057-6

Cite this article as:
Sasidharan, C.K., Sugathan, P., Mampilly, N. et al. Indian J Pediatr (2009) 76: 309. doi:10.1007/s12098-009-0057-6

Abstract

Red Baby Syndrome is a new disease seen in infants and young children. Dramatic onset of clinical symptoms with high intensity, short duration and lack of similarity with other cutaneous lesions makes it distinct. Of 50 such patients studied over a period of 5 years, half were below one year of age. Abrupt onset of high fever and generalized erythema involving the entire skin, which is swollen and tender is characteristic. These children were highly irritable and had paradoxical cry when cuddled. Rapid resolution of symptoms occurred in 7–10 days with extensive desquamation. Routine investigations were normal, C-reactive protein was raised only in 10 patients. Human Parvo virus B-19 IgM antibodies were positive in 15 out of 24 patients. Real time polymerase chain reaction was positive for human parvovirus B 19 DNA in one. Histopathological changes in the skin biopsy showed post infectious vascular injury pattern.

Key words

Red baby syndromeHuman parvovirus B19

Copyright information

© Dr. K C Chaudhuri Foundation 2009

Authors and Affiliations

  • C. K. Sasidharan
    • 1
    • 4
  • P. Sugathan
    • 1
  • Neena Mampilly
    • 1
  • Ramesh Agarwal
    • 2
  • Shashi Khare
    • 2
  • Shiv Lal
    • 2
  • C. K. Jayaram Paniker
    • 3
  1. 1.Baby Memorial HospitalCalicutIndia
  2. 2.National Institute of Communicable DiseasesDelhiIndia
  3. 3.Microbiology CentreCalicutIndia
  4. 4.ANUGRAHACalicutIndia