Association of assisted reproductive technology with twinning and congenital anomalies

  • Sevim Balci
  • Ozlem Engiz
  • Mehmet Alikasifoglu
  • Ibrahim Esinler
  • M. Sinan Beksac
Clinical Brief

DOI: 10.1007/s12098-008-0123-5

Cite this article as:
Balci, S., Engiz, O., Alikasifoglu, M. et al. Indian J Pediatr (2008) 75: 638. doi:10.1007/s12098-008-0123-5

Abstract

Recently many reports have been published on the use of intracytoplasmic sperm injection (ICSI) and the increased risk of congenital major malformations or syndromes. We present three cases with Goldenhar syndrome (one of them a twin pair) and one case with Rubinstein-Taybi syndrome (RTS), also a twin pair. All four female cases are derived from ICSI. Goldenhar syndrome with ICSI pregnancy has been reported previously but as far as we know, RTS has not been described in association with assisted reproductive technology (ART). The four new cases reported herein will contribute to a better understanding whether ICSI pregnancy increases congenital malformations.

Key words

Congenital malformation Goldenhar syndrome Intracytoplasmic sperm injection Rubinstein-Taybi syndrome Twin pregnancy 

Copyright information

© Dr. K C Chaudhuri Foundation 2008

Authors and Affiliations

  • Sevim Balci
    • 1
  • Ozlem Engiz
    • 1
  • Mehmet Alikasifoglu
    • 1
  • Ibrahim Esinler
    • 1
    • 2
  • M. Sinan Beksac
    • 1
    • 2
  1. 1.Department of Clinical GeneticsHacettepe University Faculty of Medicine, Ihsan Dogramaci Childrens’ HospitalAnkaraTurkey
  2. 2.Department of Gynecology and Obstetrics, Division of Fetal-Maternal MedicineHacettepe University Faculty of MedicineAnkaraTurkey
  3. 3.AnkaraTurkey

Personalised recommendations