Symposium on AIIMS Protocols in Neonatology — IV

The Indian Journal of Pediatrics

, Volume 75, Issue 4, pp 369-376

First online:

Chronic lung disease in newborns

  • M. Jeeva SankarAffiliated withDivision of Neonatology, Department of Pediatrics, All India Institute of Medical Sciences, Ansari Nagar
  • , Ramesh AgarwalAffiliated withDivision of Neonatology, Department of Pediatrics, All India Institute of Medical Sciences, Ansari Nagar
  • , Ashok K. DeorariAffiliated withDivision of Neonatology, Department of Pediatrics, All India Institute of Medical Sciences, Ansari Nagar Email author 
  • , Vinod K. PaulAffiliated withDivision of Neonatology, Department of Pediatrics, All India Institute of Medical Sciences, Ansari Nagar

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Abstract

Chronic lung disease (CLD) or bronchopulmonary dysplasia (BPD) occurs in preterm infants who require respiratory support in the first few days of birth. Apart from prematurity, oxygen therapy and assisted ventilation, factors like intrauterine/postnatal infections, patent ductus arteriosus, and genetic polymorphisms also contribute to its pathogenesis. The severe form of BPD with extensive inflammatory changes is rarely seen nowadays; instead, a milder form characterized by decreased alveolar septation due to arrest in lung development is more common. A multitude of strategies, mainly pharmacological and ventilatory, have been employed for prevention and treatment of BPD. Unfortunately, most of them have not been proved to be beneficial. A comprehensive protocol for management of BPD based on the current evidence is discussed here.

Key words

Bronchopulmonary dysplasia Prematurity Prevention Treatment