The Indian Journal of Pediatrics

, Volume 74, Issue 11, pp 991–994

Growth hormone in Intra-uterine growth retarded newborns

  • Sajita Setia
  • M. G. Sridhar
  • Vishnu Bhat
  • Latha Chaturvedula
Original Article

DOI: 10.1007/s12098-007-0182-z

Cite this article as:
Setia, S., Sridhar, M.G., Bhat, V. et al. Indian J Pediatr (2007) 74: 991. doi:10.1007/s12098-007-0182-z

Abstract

Objective

To study growth hormone levels in IUGR and healthy controls and its association with birth weight and ponderal index.

Methods

We studied 50 Intra uterine growth retarded (IUGR) and 50 healthy newborns born at term by vaginal delivery in JIPMER, Pondicherry, India. Cord blood was collected at the time of delivery for measurement of growth hormone.

Results

When compared with healthy newborns, IUGR newborns had higher growth hormone levels (mean ± SD, 23.5 ± 15.6 vs 16.2 ± 7.61 ngm/ml, P = 0.019). A negative correlation was identified between growth hormone levels and birth weight (r2 = − 0.22, P = 0.03) and ponderal index (r2 = − 0.36, P = 0.008). Correlation of growth hormone levels was much more confident with ponderal index than with birth weight.

Conclusion

At birth IUGR infants display increased growth hormone levels which correlate with ponderal index much more confidently than with birth weight.

Key words

IUGRGrowth hormoneIGF-1Ponderal index

Copyright information

© Dr. K C Chaudhuri Foundation 2007

Authors and Affiliations

  • Sajita Setia
    • 1
  • M. G. Sridhar
    • 1
  • Vishnu Bhat
    • 2
  • Latha Chaturvedula
    • 3
  1. 1.Department of BiochemistryJawaharlal Institute of Postgraduate Medical Education and Research PondicherryJawaharlalIndia
  2. 2.Department of PediatricsJawaharlal Institute of Postgraduate Medical Education and Research PondicherryJawaharlalIndia
  3. 3.Department of Obstetrics and GynecologyJawaharlal Institute of Postgraduate Medical Education and Research PondicherryJawaharlalIndia
  4. 4.Document Operations in Clinical (DOC), Novartis International Clinical Development Centre, iLabsHyderabadIndia