The Indian Journal of Pediatrics

, Volume 74, Issue 8, pp 759–764

Current status of iron overload and chelation with deferasirox

Special Article

DOI: 10.1007/s12098-007-0134-7

Cite this article as:
Choudhry, V.P. & Naithani, R. Indian J Pediatr (2007) 74: 759. doi:10.1007/s12098-007-0134-7


A large number of complications in thalassemia major are due mainly to iron overload. Deferoxamine in iron-overloaded patients has established that chelation therapy, when given at an adequate dose, reduces iron-related complications. Parenteral administration and the daily nuisance of an infusion pump hinder the optimal compliance. Deferiprone is moderately effective oral iron chelator. Arthralgia and cytopenias constitute the main side effects. Deferasirox is a new orally effective iron chelator which has been shown to be non-inferior to deferoxamine in clinical trials. Further clinical trials especially in Indian children will tell if it stands the test of time.

Key words

Thalassemia Iron overload Deferasirox 

Copyright information

© Dr. K C Chaudhuri Foundation 2007

Authors and Affiliations

  1. 1.Department of HematologyAll India Institute of Medical SciencesNew DelhiIndia
  2. 2.Sunflag Pahuja Centre for Blood Disorders Sunflag HospitalFaridabadIndia