Clinical and Translational Oncology

, Volume 17, Issue 2, pp 133–138

SMAD4 and TS expression might predict the risk of recurrence after resection of colorectal liver metastases

  • M. López-Gómez
  • J. Moreno-Rubio
  • I. Suárez-García
  • P. Cejas
  • R. Madero
  • E. Casado
  • A. Jiménez
  • M. Sereno
  • C. Gómez-Raposo
  • F. Zambrana
  • M. Merino
  • D. Fernández-Luengas
  • J. Feliu
Research Article

DOI: 10.1007/s12094-014-1202-x

Cite this article as:
López-Gómez, M., Moreno-Rubio, J., Suárez-García, I. et al. Clin Transl Oncol (2015) 17: 133. doi:10.1007/s12094-014-1202-x

Abstract

Purpose

Colorectal liver metastases (CLM) have significant molecular heterogeneity, which contributes to the risk of recurrence following surgery. Most of the traditional scores intended to predict recurrence is based on clinicopathological variables and it is unclear whether incorporating molecular biomarkers might improve our assessment of the risk of recurrence. Our aim was to determine if molecular biomarkers might be associated with the risk of recurrence after surgery of CLM.

Patients and methods

A total of 121 patients diagnosed with colorectal cancer (CRC) with resected liver metastases were included. The role of several clinicopathological variables to predict patient’s outcome after resection of liver metastases was analyzed. Eighteen genes related to CRC pathogenesis were also included in the analyses. Univariate and multivariate stepwise Cox regression analyses were performed to identify factors associated with recurrence and the risk of death.

Results

Eight prognostic factors for progression-free survival and nine factors for overall survival were identified in the univariate analyses. After adjusting for other risk factors, only the expression of two molecular factors was associated with the risk of recurrence: TS (HR 0.631, 95 % CI 0.422–0.944) and SMAD4 (HR 1.680, 95 % CI 1.047–2.695). None of the variables was significantly associated with the risk of death in the multivariate analyses.

Conclusions

The prognostic significance of most traditional clinicopathological variables might be insufficient to define patients at risk for recurrence after liver metastases resection. Molecular biomarkers might improve the identification of patients with higher risk of recurrence.

Keywords

Colorectal cancerResected liver metastasesPrognostic markersMolecular factors

Copyright information

© Federación de Sociedades Españolas de Oncología (FESEO) 2014

Authors and Affiliations

  • M. López-Gómez
    • 1
  • J. Moreno-Rubio
    • 2
  • I. Suárez-García
    • 3
  • P. Cejas
    • 4
  • R. Madero
    • 5
  • E. Casado
    • 1
  • A. Jiménez
    • 1
  • M. Sereno
    • 1
  • C. Gómez-Raposo
    • 1
  • F. Zambrana
    • 1
  • M. Merino
    • 1
  • D. Fernández-Luengas
    • 6
  • J. Feliu
    • 7
  1. 1.Medical OncologyInfanta Sofia University HospitalMadridSpain
  2. 2.Precision Oncology LaboratoryInfanta Sofia University HospitalMadridSpain
  3. 3.Internal MedicineInfanta Sofia University HospitalMadridSpain
  4. 4.Translational Oncology DepartmentLa Paz University HospitalMadridSpain
  5. 5.Statistics DepartmentLa Paz University HospitalMadridSpain
  6. 6.General SurgeryInfanta Sofia University HospitalMadridSpain
  7. 7.Medical OncologyLa Paz University HospitalMadridSpain