Examination of Smad2 and Smad4 copy-number variations in skin cancers
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Smad2 and Smad4 transcription factors were identified as the signalling mediators of transforming growth factor β (TGF β) pathway. Copy number variations (CNVs) have been discovered to have phenotypic consequences and be associated with various types of cancers. CNVs of Smad2 and Smad4 were found to be associated with cancer pathogenesis in the recent array-based study. However, no such study has been performed in skin cancer yet. In this study, we aim to examine the CNVs of Smad2 and Smad4 in skin samples.
A total of 195 paired samples including basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and actinic keratosis (AK) were included. Real-time PCR was used for the quantifi cation of Smad2 and Smad4 copy numbers.
CNVs of Smad2 showed statistical differences between cancer samples (both SCC and BCC) and normal tissues (p<0.05). For Smad4, statistical difference was observed only in SCC samples (p=0.014), but not in BCC and AK samples (p=0.173 and 0.314, respectively). Association analysis showed that the frequencies of Smad2 and Smad4 CNVs were correlated with the severity of skin abnormalities (p=0.002 for Smad2 and p=0.029 for Smad4).
CNVs of Smad2 are associated with SCC and BCC, while CNVs of Smad4 are associated with SCC but not BCC.
- Examination of Smad2 and Smad4 copy-number variations in skin cancers
Clinical and Translational Oncology
Volume 14, Issue 2 , pp 138-142
- Cover Date
- Print ISSN
- Online ISSN
- Springer Milan
- Additional Links
- Copy number variations
- Basal cell carcinoma
- Squamous cell carcinoma
- Actinic keratosis
- Industry Sectors
- Author Affiliations
- 1. Shenzhen Key Lab for Translational Medicine of Dermatology, Shenzhen-PKU-HKUST Medical Center, 1120 Lian-Hua Road, Fu-Tian District, Shenzhen, Guangdong, 518036, China
- 2. Biomedical Research Institute, Shenzhen-PKU-HKUST Medical Center, Shenzhen, Guangdong, China
- 3. Department of Dermatology, Shenzhen Hospital Peking University, Shenzhen, Guangdong, China
- 4. Department of General Surgery, Taizhou Municipal Hospital, Zhejiang Province, China
- 5. Division of Life Science, Hong Kong University of Science and Technology, Hong Kong, China
- 6. JNU-HKUST Joint Lab, Ji-Nan University, Guangdong, China