Special Articles

Clinical and Translational Oncology

, Volume 13, Issue 11, pp 798-804

Recommendations and expert opinion on the adjuvant treatment of colon cancer in Spain

  • José María VieitezAffiliated withHospital Universitario Central de Asturias
  • , Rocío García-CarboneroAffiliated withInstituto de Biomedicina de Sevilla (IBIS), Hospital Universitario Virgen del Rocío
  • , Jorge AparicioAffiliated withHospital Universitario La Fe
  • , Jaime FeliuAffiliated withHospital Universitario La Paz
  • , Encarnación González-FloresAffiliated withHospital Universitario Virgen de las Nieves
  • , Enrique GrandeAffiliated withHospital Universitario Ramón y Cajal
  • , Teresa Pérez-HoyosAffiliated withHospital de Basurto
  • , Antonieta SaludAffiliated withHospital Universitario Arnau de Vilanova
  • , Esperanza TorresAffiliated withHospital Universitario Virgen de la Victoria
    • , María ValeroAffiliated withHospital Universitario Central de AsturiasHospital Infanta Luisa
    • , Manuel Valladares-AyerbesAffiliated withHospital Universitario Central de AsturiasComplejo Hospital Universitario A Coruña
    • , Eduardo Díaz-RubioAffiliated withHospital Universitario Central de AsturiasMedical Oncology Department, Hospital Clínico Universitario San Carlos C/Prof. Martín Lagos, s/n Email author 

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Abstract

Adjuvant chemotherapy is the current standard in the management of patients with localised colon cancer (CC) following curative resection. The use of oxaliplatin plus 5 fluorouracil/leucovorin (FOLFOX) or oxaliplatin plus capecitabine-based (XELOX) regimens, both approved in Europe as adjuvant treatment for stage III CC, has improved prognosis in this stage, but questions on their usefulness in high-risk stage II or elderly CC patients and on the role of some prognostic biomarkers are still pending. In April 2010, a consensus meeting on adjuvant CC treatment based on a revision of the most recent literature was held in Spain. The panel considered the use of adjuvant chemotherapy for high-risk stage II CC patients to be justified. Additionally, the more convenient administration of oral fluoropyrimidines vs. IV continuous infusion 5-FU would make XELOX a more suitable alternative for the patient. A more cautious decision should be taken when prescribing oxaliplatin treatment in patients aged ≥70.

Keywords

Colorectal neoplasms Consensus Spain Antineoplastic agents Prognosis Tumour markers