Clinical and Translational Oncology

, Volume 13, Issue 11, pp 798–804

Recommendations and expert opinion on the adjuvant treatment of colon cancer in Spain

  • José María Vieitez
  • Rocío García-Carbonero
  • Jorge Aparicio
  • Jaime Feliu
  • Encarnación González-Flores
  • Enrique Grande
  • Teresa Pérez-Hoyos
  • Antonieta Salud
  • Esperanza Torres
  • María Valero
  • Manuel Valladares-Ayerbes
  • Eduardo Díaz-Rubio
Special Articles

DOI: 10.1007/s12094-011-0736-4

Cite this article as:
Vieitez, J.M., García-Carbonero, R., Aparicio, J. et al. Clin Transl Oncol (2011) 13: 798. doi:10.1007/s12094-011-0736-4

Abstract

Adjuvant chemotherapy is the current standard in the management of patients with localised colon cancer (CC) following curative resection. The use of oxaliplatin plus 5 fluorouracil/leucovorin (FOLFOX) or oxaliplatin plus capecitabine-based (XELOX) regimens, both approved in Europe as adjuvant treatment for stage III CC, has improved prognosis in this stage, but questions on their usefulness in high-risk stage II or elderly CC patients and on the role of some prognostic biomarkers are still pending. In April 2010, a consensus meeting on adjuvant CC treatment based on a revision of the most recent literature was held in Spain. The panel considered the use of adjuvant chemotherapy for high-risk stage II CC patients to be justified. Additionally, the more convenient administration of oral fluoropyrimidines vs. IV continuous infusion 5-FU would make XELOX a more suitable alternative for the patient. A more cautious decision should be taken when prescribing oxaliplatin treatment in patients aged ≥70.

Keywords

Colorectal neoplasmsConsensusSpainAntineoplastic agentsPrognosisTumour markers

Copyright information

© Feseo 2011

Authors and Affiliations

  • José María Vieitez
    • 1
  • Rocío García-Carbonero
    • 2
  • Jorge Aparicio
    • 3
  • Jaime Feliu
    • 4
  • Encarnación González-Flores
    • 5
  • Enrique Grande
    • 6
  • Teresa Pérez-Hoyos
    • 7
  • Antonieta Salud
    • 8
  • Esperanza Torres
    • 9
  • María Valero
    • 10
  • Manuel Valladares-Ayerbes
    • 11
  • Eduardo Díaz-Rubio
    • 12
  1. 1.Hospital Universitario Central de AsturiasOviedo, AsturiasSpain
  2. 2.Instituto de Biomedicina de Sevilla (IBIS)Hospital Universitario Virgen del RocíoSevillaSpain
  3. 3.Hospital Universitario La FeValenciaSpain
  4. 4.Hospital Universitario La PazMadridSpain
  5. 5.Hospital Universitario Virgen de las NievesGranadaSpain
  6. 6.Hospital Universitario Ramón y CajalMadridSpain
  7. 7.Hospital de BasurtoBilbao, VizcayaSpain
  8. 8.Hospital Universitario Arnau de VilanovaLleidaSpain
  9. 9.Hospital Universitario Virgen de la VictoriaMálagaSpain
  10. 10.Hospital Infanta LuisaSevillaSpain
  11. 11.Complejo Hospital Universitario A CoruñaA CoruñaSpain
  12. 12.Medical Oncology DepartmentHospital Clínico Universitario San Carlos C/Prof. Martín Lagos, s/nMadridSpain