Consensus of the Spanish Society of Medical Oncology (SEOM) and Spanish Society of Pathology (SEAP) for HER2 testing in gastric carcinoma

  • Carlos Gómez-Martín
  • Ángel Concha
  • José María Corominas
  • Tomás García-Caballero
  • Elena García-García
  • Mar Iglesias
  • José Antonio López
  • Santiago Ramón y Cajal
  • Federico Rojo
  • José Palacios
  • Francisco Vera-Sempere
  • Enrique Aranda
  • Ramon Colomer
  • Pilar García-Alfonso
  • Pilar Garrido
  • Fernando Rivera
  • Fernando López-Ríos
Special Article

DOI: 10.1007/s12094-011-0709-7

Cite this article as:
Gómez-Martín, C., Concha, Á., Corominas, J.M. et al. Clin Transl Oncol (2011) 13: 636. doi:10.1007/s12094-011-0709-7

Abstract

The identification of HER2 alterations in advanced gastric carcinomas is of critical importance in daily clinical practice as such neoplasms require specific treatment with trastuzumab. For these reasons, pathologists and oncologists with expertise in gastric carcinomas and HER2 testing from both organisations (SEAP and SEOM) have endeavoured to discuss and agree on national guidelines for HER2 testing in gastric carcinomas. These guidelines are based on the experience of those who participated in the discussions and also on experience published internationally. These agreed guidelines give the minimum requirements that a pathological anatomy laboratory must fulfil in order to guarantee adequate HER2 testing in daily practice. Any laboratories which do not meet the minimum standards set out in the guidelines must make every effort to achieve compliance.

Keywords

Gastric carcinomaHER2StandardisationImmunohistochemistryIn situ hybridisationQuality control

Copyright information

© Feseo 2011

Authors and Affiliations

  • Carlos Gómez-Martín
    • 1
  • Ángel Concha
  • José María Corominas
  • Tomás García-Caballero
  • Elena García-García
  • Mar Iglesias
  • José Antonio López
  • Santiago Ramón y Cajal
  • Federico Rojo
  • José Palacios
  • Francisco Vera-Sempere
  • Enrique Aranda
  • Ramon Colomer
  • Pilar García-Alfonso
  • Pilar Garrido
  • Fernando Rivera
  • Fernando López-Ríos
  1. 1.GI Cancer Research Unit Clinical Research ProgrammeNational Cancer Research Centre (CNIO)MadridSpain