Educational Series Advances in Clinical Management and Therapy of Cancer

Clinical and Translational Oncology

, Volume 13, Issue 3, pp 162-178

First online:

Treatment recommendations for metastatic colorectal cancer

  • Enrique ArandaAffiliated withMedical Oncology Department, Hospital Universitario Reina Sofía Email author 
  • , Albert AbadAffiliated withHospital Germans Trias i Pujol-ICO
  • , Alfredo CarratoAffiliated withHospital Ramón y Cajal
  • , Andrés CervantesAffiliated withHospital Clínico
  • , Jesús García-FoncillasAffiliated withClínica de Navarra
  • , Pilar García AlfonsoAffiliated withHospital Gregorio Marañón
  • , Rocío García CarboneroAffiliated withInstituto de Biomedicina de Sevilla (IBIS), Hospital Universitario Virgen del Rocío
  • , Auxiliadora Gómez EspañaAffiliated withMedical Oncology Department, Hospital Universitario Reina Sofía
  • , Josep M. TaberneroAffiliated withHospital Vall d’Hebron
    • , Eduardo Díaz-RubioAffiliated withHospital Clínico San Carlos

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Abstract

Metastatic colorectal cancer (CRC) represents an important health problem in which several biological predictive and prognostic factors have been identified, including clinical features and molecular markers that might influence the response to treatment. Actually, certain prognostic factors are considered key elements, along with disease extent, for deciding the therapeutic approach. However, a distinction between resectable/potentially resectable and unresectable patients must be made in order to establish an adequate therapeutic strategy. Different drugs and chemotherapy regimens are currently available, and their administration depends on patient characteristics, disease-related factors and the treatment objective. Moreover, special situations such as peritoneal carcinomatosis and local treatment of CRC in the setting of metastatic disease should be considered when deciding the most appropriate treatment strategy. This article reviews all the previously mentioned issues involved in the management of metastatic CRC and suggests some general recommendations for its treatment.

Keywords

Metastatic colorectal cancer Chemotherapy