Clinical and Translational Oncology

, Volume 12, Issue 12, pp 843–848

Efficacy of epoetin-beta 30,000 IU/week in correcting anaemia in patients with gastrointestinal tumours subjected to concomitant chemoradiotherapy

Authors

    • Servicio de Oncología RadioterápicaHospital Clínico Universitario Santiago de Compostela
  • Mercedes Salgado
    • Servicio de Oncología MédicaComplejo Hospitalario de Orense
  • Manuel Valladares-Ayerbes
    • Servicio de Oncología MédicaComplejo Hospitalario Universitario de La Coruña
  • Mónica Jorge
    • Servicio de Oncología MédicaComplejo Hospitalario de Vigo
  • Ana Carballo
    • Servicio de Oncología RadioterápicaHospital Clínico Universitario Santiago de Compostela
  • Sonia Candamio
    • Servicio de Oncología MédicaComplejo Hospitalario Universitario
  • Pilar Izquierdo
    • Servicio de Oncología MédicaComplejo Hospitalario Universitario
  • Paula Peleteiro
    • Servicio de Oncología RadioterápicaHospital Clínico Universitario Santiago de Compostela
  • Rafael López
    • Servicio de Oncología RadioterápicaCentro Oncológico de La Coruña
Research Articles

DOI: 10.1007/s12094-010-0607-4

Cite this article as:
Gómez, A., Salgado, M., Valladares-Ayerbes, M. et al. Clin Transl Oncol (2010) 12: 843. doi:10.1007/s12094-010-0607-4

Abstract

Objective

The aim of the project was to assess the effectiveness and safety of weekly epoetin-beta (EB) in patients with gastrointestinal cancer (GIC) subjected to concomitant chemoradiotherapy (CCTRT).

Methods

In this clinical prospective and multicentre cohort study EB was administered at a dose of 30,000 IU/ week, during CCTRT and in the four weeks thereafter, and suspended if haemoglobin (Hb) increased >2 g/dl or Hb >12–13 g/dl. Effectiveness was defined as Hb increase ≥1 g/dl vs. baseline. Time to response, treatment toxicity and transfusion requirements were also assessed.

Results

EB was effective in 75.8% of the evaluable population within a median of four weeks from EB initiation, without blood transfusions. Over 80% of all patients remained below the threshold (Hb ≤13 g/dl) and no study drug-related adverse reactions were recorded.

Conclusion

Weekly EB proved to be effective and well tolerated by patients with GIC subjected to CCTRT.

Keywords

Gastrointestinal cancer Epoetin-beta Anaemia

Copyright information

© Feseo 2010