Clinical and Translational Oncology

, Volume 12, Issue 12, pp 794–804

Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal malignant disease

  • Wenceslao Vásquez Jiménez
  • Luis González Bayón
  • José Luis García-Sabrido
  • Santiago González Moreno
Educational Series/Red Series Current Technology in Cancer Research and Treatment

DOI: 10.1007/s12094-010-0601-x

Cite this article as:
Vásquez Jiménez, W., González Bayón, L., García-Sabrido, J.L. et al. Clin Transl Oncol (2010) 12: 794. doi:10.1007/s12094-010-0601-x

Abstract

Peritoneal Malignant Disease (PMD) is the presence of tumoral tissue on the peritoneal surface from primary tumors or tumors from other locations (e.g. digestive or gynecologic). It is a regional disease with poor prognosis when treated with repeated “debulking” and traditional systemic chemotherapy. Cytoreduction plus hyperthermic intraperitoneal chemotherapy (HIPEC) is a combined multimodal regional procedure aimed at reducing the macroscopic tumoral mass as much as possible and treating with chemotherapy the microscopic disease that is out of the scope of the surgeon. This combined treatment may change the natural history of PMD, it is translated into a higher overall survival and cancer-free survival and it offers the option of cure in selected cases. The high-complexity procedure is also associated with complications and mortality, but in similar rates as other major oncologic procedures.

Keywords

Cytoreductive surgery Hyperthermic intraperitoneal chemotherapy Peritoneal malignant disease Carcinomatosis 

Copyright information

© Feseo 2010

Authors and Affiliations

  • Wenceslao Vásquez Jiménez
    • 1
  • Luis González Bayón
    • 1
  • José Luis García-Sabrido
    • 1
  • Santiago González Moreno
    • 2
  1. 1.Department of General SurgeryGregorio Marañón General HospitalMadridSpain
  2. 2.Department of Surgical Oncology Peritoneal Surface Oncology ProgramCentro Oncológico M. D. Anderson International EspañaMadridSpain

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