Educational Series Molecular and Cellular Biology of Cancer

Clinical and Translational Oncology

, Volume 12, Issue 9, pp 590-596

Genetic alterations in children and adolescents with acute myeloid leukaemia

  • Amparo VerdeguerAffiliated withPediatric Oncology and Pediatric Hematopoietic Cell Transplantation Unit Clinical and Translational Investigation Group La Fe, Hospital Universitario Infantil La Fe Email author 

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Abstract

Acute Myeloid Leukemia is a clinically and genetically heterogeneous disease, in which cytogenetic aberrations are the most important factors to determine biological behavior and prognosis. More than 20 different chromosomal abnormalities have been identified in a high percentage of children (70–85%) with the novo AML. We reviewed the most frequently found and the impact of these aberrations on prognosis. Differences according to the age of patients and mainly in relation to adult population have been enhanced, although the low incidence of AML in children and the high number of abnormalities make difficult to accurately define the prognosis significance of these aberrations.

Keywords

Pediatric acute myeloid leukemia Cytogenetics Molecular rearrangements Prognostic factors Leukemogenesis