Clinical and Translational Oncology

, Volume 12, Issue 7, pp 473–480

Patient-derived human tumour tissue xenografts in immunodeficient mice: a systematic review

  • Ketao Jin
  • Lisong Teng
  • Yanping Shen
  • Kuifeng He
  • Zhenzhen Xu
  • Guangliang Li
Educational Series Current Technology in Cancer Research and Treatment

DOI: 10.1007/s12094-010-0540-6

Cite this article as:
Jin, K., Teng, L., Shen, Y. et al. Clin Transl Oncol (2010) 12: 473. doi:10.1007/s12094-010-0540-6

Abstract

Mouse cancer models have consistently been used to qualify new anticancer drugs in the development of human clinical trials. Rodent tumour models currently being used and which include transgenic tumour models, and those generated by planting human tumour cell lines subcutaneously in immunodeficient mice, do not sufficiently represent clinical cancer characteristics, especially with regard to metastasis and drug sensitivity. The increasingly used patient-derived human tumour tissue (PDTT) xenografts models implanted subcutaneously or in subrenal capsule in immunodeficient mice, such as athymic nude mice or severe combined immune deficient (SCID) mice, may provide a more accurate reflection of human tumour biological characteristics than tumour cell lines. The ability to passage patients’ fresh tumour tissues into large numbers of immunodeficient mice provides possibilities for better preclinical testing of new therapies for the treatment and better outcome for cancer. In this review, we outline the methods of establishing xenograft models, discuss the biological stability of PDTT xenograft models and demonstrate their roles in developing new anticancer drugs and testing therapeutic regimens in cancer patients.

Keywords

Biologic stability Cancer Preclinical application Tumour models Xenograft 

Copyright information

© Feseo 2010

Authors and Affiliations

  • Ketao Jin
    • 1
    • 2
  • Lisong Teng
    • 1
  • Yanping Shen
    • 1
  • Kuifeng He
    • 1
  • Zhenzhen Xu
    • 3
  • Guangliang Li
    • 1
  1. 1.Department of Surgical Oncology First Affiliated HospitalCollege of Medicine Zhejiang UniversityHangzhou, ZhejiangChina
  2. 2.Department of SurgeryZhuji HospitalZhuji, ZhejiangChina
  3. 3.Sir Run Run Shaw Institute of Clinical MedicineZhejiang University Key Laboratory of Biotherapy of Zhejiang ProvinceHangzhou, ZhejiangChina