Clinical and Translational Oncology

, Volume 12, Issue 6, pp 431–436

Update on the surgical pathology standards on rectal cancer diagnosis, staging and quality assessment of surgery

Authors

    • Department of PathologyM.D. Anderson International España
  • Gemma Toledo
    • Department of PathologyM.D. Anderson International España
  • Juan F. García
    • Department of PathologyM.D. Anderson International España
  • Pilar Sancho
    • Department of Medical OncologyM.D. Anderson International España
  • Sara Encinas
    • Department of Medical OncologyM.D. Anderson International España
  • Óscar Alonso
    • Department of Surgical OncologyM.D. Anderson International España
Special Article

DOI: 10.1007/s12094-010-0530-8

Cite this article as:
Rojo, A., Toledo, G., García, J.F. et al. Clin Transl Oncol (2010) 12: 431. doi:10.1007/s12094-010-0530-8

Abstract

Surgery for rectal cancer continues to develop towards improving local control and overall survival, maintaining quality of life and preserving sphincter, genitourinary and sexual function. The multidisciplinary approach integrated in a team of different specialists ensures an individualised treatment for each patient with rectal cancer. Thus, the role of the pathologist has acquired an important relevance, not only in diagnosis, management and evaluation of the surgical specimen, but also for selection of the best adjuvant treatment. Parameters such as macroscopic quality of the mesorectum, status of the circumferential margin and lymph node harvest are considered basic criteria by current guidelines. Additionally, consistency in reporting based on the histologic classification proposed by the World Health Organization (WHO) is mandatory, along with inclusion into the pathologic report of current criteria for tumour node metastasis (TNM) staging, assessment of response to neoadjuvant chemoradiation therapy and clinically relevant molecular studies. Detection of defects in mismatch repair genes and mutational analysis of specific genes should be included as predictive markers for therapy.

Keywords

Rectal cancerPathologyUpdateDiagnosisQuality control

Copyright information

© Feseo 2010