Clinical and Translational Oncology

, Volume 12, Issue 5, pp 326–338

The insulin-like growth factor pathway as a target for cancer therapy

  • Iker López-Calderero
  • Elizabeth Sánchez Chávez
  • Rocío García-Carbonero
Educational Series Molecular Targets in Oncology

DOI: 10.1007/s12094-010-0514-8

Cite this article as:
López-Calderero, I., Sánchez Chávez, E. & García-Carbonero, R. Clin Transl Oncol (2010) 12: 326. doi:10.1007/s12094-010-0514-8

Abstract

The insulin-like growth factor (IGF) system is emerging as a promising new target in cancer therapy. Experimental models and epidemiological studies have demonstrated that the IGF system plays a key role in malignant transformation and cancer progression. Different strategies are being pursued to target this pathway. Several monoclonal antibodies and tyrosine kinase inhibitors targeting the IGF-1 receptor are in clinical development. Early clinical trials indicate these drugs have acceptable safety profiles, and there is pharmacodynamic evidence that actual target inhibition is achievable in patients. Emerging efficacy data as single agent and in combination with chemotherapy is encouraging yet too early for firm conclusions. This manuscript reviews the role of the IGF system in human malignancy and its interactions with other signaling pathways, and summarizes the available data of IGF-1R inhibitors currently in clinical trials.

Keywords

IGF-1 pathwayReviewAnticancer therapyMonoclonal antibodiesTyrosine kinase inhibitors

Copyright information

© Feseo 2010

Authors and Affiliations

  • Iker López-Calderero
    • 1
  • Elizabeth Sánchez Chávez
    • 1
  • Rocío García-Carbonero
    • 1
  1. 1.Department of Medical OncologyHospital Universitario Virgen del Rocío Instituto de Biomedicina de Sevilla (IBIS)SevillaSpain