Clinical and Translational Oncology

, Volume 11, Issue 10, pp 659–668

Clinical relevance associated to the analysis of circulating tumour cells in patients with solid tumours

  • Ma. José Serrano Fernández
  • Juan Carlos Álvarez Merino
  • Iñigo Martínez Zubiaurre
  • Ana Fernández García
  • Pedro Sánchez Rovira
  • José Antonio Lorente Acosta
Reviews

DOI: 10.1007/s12094-009-0421-z

Cite this article as:
Serrano Fernández, M.J., Álvarez Merino, J.C., Martínez Zubiaurre, I. et al. Clin Transl Oncol (2009) 11: 659. doi:10.1007/s12094-009-0421-z

Abstract

The distant growth of tumour cells escaping from primary tumours, a process termed metastasis, represents the leading cause of death among patients affected by malignant neoplasias from breast and colon. During the metastasis process, cancer cells liberated from primary tumour tissue, also termed circulating tumour cells (CTCs), travel through the circulatory and/or lymphatic systems to reach distant organs. The early detection and the genotypic and phenotypic characterisation of such CTCs could represent a powerful diagnostic tool of the disease, and could also be considered an important predictive and prognostic marker of disease progression and treatment response. In this article we discuss the potential relevance in the clinic of monitoring CTCs from patients suffering from solid epithelial tumours, with emphasis on the impact of such analyses as a predictive marker for treatment response.

Keywords

Circulating tumour cellsPeripheral bloodCytokeratinBreast cancerLung cancerColon cancerImmunomagnetic separation

Copyright information

© Feseo 2009

Authors and Affiliations

  • Ma. José Serrano Fernández
    • 1
  • Juan Carlos Álvarez Merino
    • 1
    • 2
  • Iñigo Martínez Zubiaurre
    • 3
  • Ana Fernández García
    • 1
  • Pedro Sánchez Rovira
    • 4
  • José Antonio Lorente Acosta
    • 1
    • 2
  1. 1.Center GENYO (Pfizer-University of Granada-Andalucian Goverment Center for Genomics and Oncological Research)Armilla, GranadaSpain
  2. 2.Department of Legal MedicineUniversity of GranadaGranadaSpain
  3. 3.Institute of Clinical Medicine Medicine FacultyUniversity of TromsøTromsøNorway
  4. 4.Medical Oncology DepartmentUniversity HospitalJaénSpain