Clinical and Translational Oncology

, Volume 11, Issue 4, pp 194–198

Genetic alterations in chronic lymphocytic leukaemia

Authors

  • Llorenç Coll-Mulet
    • Departament de Ciències Fisiològiques IIIDIBELL-Universitat de Barcelona Campus de Bellvitge
    • Departament de Ciències Fisiològiques IIIDIBELL-Universitat de Barcelona Campus de Bellvitge
Educational Series Molecular and Cellular Biology of Cancer

DOI: 10.1007/s12094-009-0340-z

Cite this article as:
Coll-Mulet, L. & Gil, J. Clin Transl Oncol (2009) 11: 194. doi:10.1007/s12094-009-0340-z

Abstract

Chronic lymphocytic leukaemia (CLL), the commonest form of leukaemia in adults in Western countries, is a genetically heterogeneous disease. The most frequent genetic alterations are deletions in 13q14, 17p13 (TP53) and 11q22–q23 (ATM), and trisomy of chromosome 12. Furthermore, additional alterations have been described. The most relevant techniques used for detection of genetic alterations in CLL include comparative genomic hybridisation (CGH) and fluorescence in situ hybridisation (FISH). Recently, PCR-based techniques, such as multiplex ligation-dependent probe amplification (MLPA), have been used to detect genetic alterations in CLL. This review summarises the genetic alterations described in CLL and the techniques used for their detection.

Keywords

Chronic lymphocytic leukaemiaTP53ATMMicroRNAsFISHMLPA
Download to read the full article text

Copyright information

© Feseo 2009