Clinical and Translational Oncology

, Volume 11, Issue 1, pp 11–19

Notch signalling in cancer stem cells

  • Victoria Bolós
  • Moisés Blanco
  • Vanessa Medina
  • Guadalupe Aparicio
  • Silvia Díaz-Prado
  • Enrique Grande
Educational Series Molecular Targets in Oncology

DOI: 10.1007/s12094-009-0305-2

Cite this article as:
Bolós, V., Blanco, M., Medina, V. et al. Clin Transl Oncol (2009) 11: 11. doi:10.1007/s12094-009-0305-2

Abstract

A new theory about the development of solid tumours is emerging from the idea that solid tumours, like normal adult tissues, contain stem cells (called cancer stem cells) and arise from them. Genetic mutations encoding for proteins involved in critical signalling pathways for stem cells such as BMP, Notch, Hedgehog and Wnt would allow stem cells to undergo uncontrolled proliferation and form tumours. Taking into account that cancer stem cells (CSCs) would represent the real driving force behind tumour growth and that they may be drug resistant, new agents that target the above signalling pathways could be more effective than current anti-solid tumour therapies. In the present paper we will review the molecular basis of the Notch signalling pathway. Additionally, we will pay attention to their role in adult stem cell self-renewal, and cell fate specification and differentiation, and we will also review evidence that supports their implication in cancer.

Keywords

Notch pathwayCancer stem cells

Copyright information

© Feseo 2009

Authors and Affiliations

  • Victoria Bolós
    • 1
  • Moisés Blanco
    • 2
  • Vanessa Medina
    • 2
    • 3
  • Guadalupe Aparicio
    • 3
  • Silvia Díaz-Prado
    • 2
    • 4
  • Enrique Grande
    • 1
  1. 1.Medical Oncology DepartmentPfizer SpainAlcobendas, MadridSpain
  2. 2.Institute for Biomedical Research (INIBIC)A Coruña University HospitalA CoruñaSpain
  3. 3.Oncology Research UnitA Coruña University HospitalA CoruñaSpain
  4. 4.Medicine DepartmentUniversity of A CoruñaA CoruñaSpain