Clinical and Translational Oncology

, Volume 10, Issue 12, pp 786–793

An update on the biology of cancer stem cells in breast cancer

Authors

  • José María García Bueno
    • Stem Cell Laboratory, Regional Centre for Biomedical ResearchUniversity of Castilla-La Mancha
    • Unidad de OncologíaCHUA
  • Alberto Ocaña
    • Stem Cell Laboratory, Regional Centre for Biomedical ResearchUniversity of Castilla-La Mancha
    • Unidad de OncologíaCHUA
  • Paola Castro-García
    • Stem Cell Laboratory, Regional Centre for Biomedical ResearchUniversity of Castilla-La Mancha
    • Laboratorio de Células Madre/CRIBUniversidad de Castilla-La Mancha
  • Carmen Gil Gas
    • Stem Cell Laboratory, Regional Centre for Biomedical ResearchUniversity of Castilla-La Mancha
    • Laboratorio de Células Madre/CRIBUniversidad de Castilla-La Mancha
  • Francisco Sánchez-Sánchez
    • Área de Genética Facultad de Medicina/CRIB
  • Enrique Poblet
    • Stem Cell Laboratory, Regional Centre for Biomedical ResearchUniversity of Castilla-La Mancha
    • Unidad de Anatomía PatológicaCHUA
  • Rosario Serrano
    • Stem Cell Laboratory, Regional Centre for Biomedical ResearchUniversity of Castilla-La Mancha
  • Raúl Calero
    • Stem Cell Laboratory, Regional Centre for Biomedical ResearchUniversity of Castilla-La Mancha
    • Stem Cell Laboratory, Regional Centre for Biomedical ResearchUniversity of Castilla-La Mancha
    • Laboratorio de Células Madre/CRIBUniversidad de Castilla-La Mancha
Educational Series

DOI: 10.1007/s12094-008-0291-9

Cite this article as:
García Bueno, J.M., Ocaña, A., Castro-García, P. et al. Clin Transl Oncol (2008) 10: 786. doi:10.1007/s12094-008-0291-9

Abstract

Breast cancer stem cells are defined as cancer cells with self-renewal capacity. These cells represent a small subpopulation endowed with the ability to form new tumours when injected in nude mice. Markers of differentiation have been used to identify these cancer cells. In the case of breast cancer, CD44+/CD24− select a population with stem cell properties. The fact that these cells have self-renewal ability has suggested that this population could be responsible for new tumour formation and cancer relapse. These cells have been shown to be more resistant to chemotherapy and radiotherapy than normal cancer cells. The identification of the molecular druggable alterations responsible for the initiation and maintenance of cancer stem cells is an important goal. In this article we will review all these points with special emphasis on the possible role of new drugs designed to interact with molecular pathways of cancer stem cells.

Keywords

Breast cancerCancer Stem CellCancerABC transportersTarget therapiesPEDFNotchWntHedgehog

Copyright information

© Feseo 2008