Clinical and Translational Oncology

, Volume 9, Issue 7, pp 443–451

Update in the management of ovarian and cervical carcinoma

  • A. Poveda
  • R. Salazar
  • J. M. del Campo
  • C. Mendiola
  • J. Cassinello
  • B. Ojeda
  • J. A. Arranz
  • A. Oaknin
  • J. García-Foncillas
  • M. J. Rubio
  • A. González Martín
Special Article

DOI: 10.1007/s12094-007-0083-7

Cite this article as:
Poveda, A., Salazar, R., del Campo, J.M. et al. Clin Transl Oncol (2007) 9: 443. doi:10.1007/s12094-007-0083-7

Abstract

Ovarian and cervical cancers are significant health problems. This article provides an update in selected management topics. Paclitaxel and platinum derivatives are the first-line treatment for patients with advanced disease. In selected patients, intraperitoneal chemotherapy has been associated with improved survival but the broad applicability of this strategy is limited by issues of toxicity and feasibility. Management of patients with recurrent disease is based on a number of factors and includes surgery in selected cases, platinum-based chemotherapy for patients with platinum-sensitive disease and other agents such as topotecan and pegylated liposomal formulation of doxorubicin for patients with platinum-resistant disease. In cervical cancer, the most significant issue/event is the demonstration of superior survival with topotecan and cisplatin compared to cisplatin alone. Finally, new agents such as epidermal growth factor receptor inhibitors and antiangiogenic agents are being currently tested in these settings.

Key words

Ovarian cancerChemotherapyCervical cancerUpdate

Copyright information

© Feseo 2007

Authors and Affiliations

  • A. Poveda
    • 1
  • R. Salazar
    • 2
  • J. M. del Campo
    • 3
  • C. Mendiola
    • 4
  • J. Cassinello
    • 5
  • B. Ojeda
    • 6
  • J. A. Arranz
    • 7
  • A. Oaknin
    • 2
  • J. García-Foncillas
    • 8
  • M. J. Rubio
    • 9
  • A. González Martín
    • 10
  1. 1.Servicio de Oncología MédicaInstituto Valenciano de OncologíaValenciaSpain
  2. 2.Instituto Catalán de OncologíaBarcelonaSpain
  3. 3.Division of Medical OncologyHospital Vall d’HebrónBarcelonaSpain
  4. 4.Division of Medical OncologyUniversity Hospital 12 de OctubreMadridSpain
  5. 5.Division of Medical OncologyHospital Universitario de GuadalajaraGuadalajaraSpain
  6. 6.Division of Medical OncologyHospital de Sant PauBarcelonaSpain
  7. 7.Division of Medical OncologyHospital General Universitario Gregorio MarañónMadridSpain
  8. 8.Division of Medical OncologyClínica Universitaria de NavarraPamplonaSpain
  9. 9.Division of Medical OncologyHospital Reina SofíaCórdobaSpain
  10. 10.Hospital Universitario Ramón y CajalMadridSpain