Clinical and Translational Oncology

, Volume 8, Issue 10, pp 729–734

Colony-stimulating factors: clinical evidence for treatment and prophylaxis of chemotherapy-induced febrile neutropenia

  • César Gómez Raposo
  • Álvaro Pinto Marín
  • Manuel González Barón
Review

DOI: 10.1007/s12094-006-0119-4

Cite this article as:
Raposo, C.G., Marín, Á.P. & Barón, M.G. Clin Transl Oncol (2006) 8: 729. doi:10.1007/s12094-006-0119-4

Abstract

The hematopoietic growth factors (HGFs) are a family of glycoproteins which plays a major role in the proliferation, differentiation, and survival of primitive hematopoietic stem and progenitor cells, and in the functions of some mature cells. More than 20 different molecules of HGF have been identified. Among them, granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) have been demostrated to be effective in reducing the incidence of febrile neutropenia when administered inmediately after chemotherapy and as supportive therapy in patients undergoing bone marrow transplantation. Chemotherapy used for treatment of cancer often causes neutropenia, which may be profound, requiring hospitalization, and leading to potentially fatal infection. The uses of the recombinant human hematopoietic colony-stimulating factors G-CSF and GM-CSF for treatment and prophylaxis of chemotherapy-induced febrile neutropenia will be reviewed here.

Key words

hematopoietic growth factorscolony-stimulating factorsfebrile neutropeniachemotherapy induced neutropeniadose intensitychemotherapy

Copyright information

© FESEO 2006

Authors and Affiliations

  • César Gómez Raposo
    • 1
  • Álvaro Pinto Marín
    • 1
  • Manuel González Barón
    • 1
  1. 1.Servicio de Oncología MédicaHospital Universitario La PazMadridSpain