Clinical and Translational Oncology

, Volume 8, Issue 10, pp 717–728

Anticancer drug discovery and pharmaceutical chemistry: a history

Educational Series Red Series

DOI: 10.1007/s12094-006-0118-5

Cite this article as:
Braña, M.F. & Sánchez-Migallón, A. Clin Transl Oncol (2006) 8: 717. doi:10.1007/s12094-006-0118-5


There are several procedures for the chemical discovery and design of new drugs from the point of view of the pharmaceutical or medicinal chemistry. They range from classical methods to the very new ones, such as molecular modeling or high throughput screening. In this review, we will consider some historical approaches based on the screening of natural products, the chances for luck, the systematic screening of new chemical entities and serendipity. Another group comprises rational design, as in the case of metabolic pathways, conformation versus configuration and, finally, a brief description on available new targets to be carried out. In each approach, the structure of some examples of clinical interest will be shown.

Key words

drug discoverydrug designorganic chemistry of anticancer drugs

Copyright information

© FESEO 2006

Authors and Affiliations

  1. 1.Instituto Canario de Investigación del Cáncer (ICIC)MadridSpain
  2. 2.Universidad de Castilla-La ManchaSpain