, Volume 8, Issue 3, pp 161-172

Genomic platforms for cancer research: potential diagnostic and prognostic applications in clinical oncology

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Summary

The completion of the Human Genome Project and the achievement of similar goals in other organisms have generated a huge a mount of free available information with high potential in biomedical sciences. However, the identification of the DNA sequences was only a starting point for genomic research. This research has been facilitated by the development of new powerful genomic tools that allow the use of the wide amount of genomic information generate to address new biological and biomedical questions. One of these widely accepted and accessible technologies is DNAmicroarrays. Although the most popular use of DNAmicroarrays is gene expression profiling, due to the continous advances inmicroarray technologies, scientists have also successfully used them for multiple applications, including genotyping, re-sequencing, DNA copy number analysis and DNA methylation. In short, DNAmicroarrays are changing the way cancer research scientists are addressing different biological questions and will allow the translation of genome research to clinical practice.

Supported by an unrestricted educational grant from AstraZeneca.