Hepatology International

, Volume 8, Issue 3, pp 316–320

Hedgehog signaling and radiation induced liver injury: a delicate balance

Review Article

DOI: 10.1007/s12072-014-9532-x

Cite this article as:
Kabarriti, R. & Guha, C. Hepatol Int (2014) 8: 316. doi:10.1007/s12072-014-9532-x

Abstract

Radiation-induced liver disease (RILD) is a major limitation of radiation therapy (RT) for the treatment of liver cancer. Emerging data indicate that hedgehog (Hh) signaling plays a central role in liver fibrosis and regeneration after liver injury. Here, we review the potential role of Hh signaling in RILD and propose the temporary use of Hh inhibition during liver RT to radiosensitize HCC tumor cells and inhibit their progression, while blocking the initiation of the radiation-induced fibrotic response in the surrounding normal liver.

Keywords

Radiation-induced liver disease Hedgehog signaling 

Abbreviations

EMT

Epithelial–mesenchymal transition

GLI

Glioblastoma family

Hh

Hedgehog

Hhip

Hedgehog interacting protein

IHH

Indian hedgehog

LSECs

Liver sinusoidal endothelial cells

RILD

Radiation-induced liver disease

SHH

Sonic hedgehog

SOS

Sinusoidal obstructive syndrome

TGF-β

Transforming growth factor-β

VOD

Veno-occlusive disease

Copyright information

© Asian Pacific Association for the Study of the Liver 2014

Authors and Affiliations

  1. 1.Department of Radiation Oncology, Montefiore Medical CenterAlbert Einstein College of MedicineBronxUSA
  2. 2.Department of Pathology, Montefiore Medical CenterAlbert Einstein College of MedicineBronxUSA

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