IL28B polymorphisms predict the virological response to standard therapy in patients with chronic hepatitis C virus genotype 4 infection
Genome-wide association studies have recently revealed that several single-nucleotide polymorphisms (SNPs) in the interleukin (IL) 28B genes can predict the sustained virological response (SVR) to pegylated interferon-α2a/b plus ribavirin in hepatitis C virus (HCV)-genotype 1 patients. However, data for patients infected with HCV genotype 4 (HCV-G4) are limited.
We analyzed the association of IL28B SNPs (hematological, biochemical, virological, and pathological factors) with SVR in the HCV-G4 monoinfected cohort of patients.
Patients and methods
One hundred twenty-nine treatment-naïve HCV-G4 patients undergoing treatment were recruited from three tertiary care centers in Saudi Arabia. Five IL28B SNPs (rs12979860, rs12980275, rs8105790, rs8099917, and rs72486680) were identified by polymerase chain reaction and DNA sequencing. SVR was statistically correlated with various clinical, histopathological, virological, and genetic parameters.
SVR was significantly associated with the CC and AA alleles of rs12979860 (p = 0.008) and rs12980275 (p = 0.004), respectively. Moreover, albumin levels (p = 0.002) and platelet count (p = 0.039) showed significant differences in the SVR and No SVR groups. On multivariate analysis, the CC allele of rs12979860 (OR, 2.89; 95 % CI 1.6–6.2, p = 0.006) and albumin levels (OR, 1.2; 95 % CI 1.1–1.4, p = 0.001) independently predicted SVR.
IL28B polymorphism (CC allele of rs12979860) predicts the sustained response to antiviral therapy in HCV-G4.
- IL28B polymorphisms predict the virological response to standard therapy in patients with chronic hepatitis C virus genotype 4 infection
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- Available under Open Access This content is freely available online to anyone, anywhere at any time.
Volume 7, Issue 2 , pp 533-538
- Cover Date
- Print ISSN
- Online ISSN
- Springer India
- Additional Links
- Hepatitis C
- Genotype 4
- Sustained virological response
- Single nucleotide polymorphism
- Industry Sectors
- Ayman A. Abdo (1) (2)
- Mohammed N. Al-Ahdal (3)
- Saira S. Khalid (2)
- Ahmed Helmy (2) (4)
- Faisal M. Sanai (2) (5)
- Khalid Alswat (1) (2)
- Waleed Al-hamoudi (1) (2)
- Safiyya M. Ali (2)
- Hamad I. Al-Ashgar (6)
- Abdallah Al-Mdani (7)
- Ali Albenmousa (7)
- Faleh Z. Al Faleh (1)
- Mashael Al-Anazi (3)
- Nisreen Khalaf (3)
- Ahmed Al-Qahtani (2) (3)
- Author Affiliations
- 1. Division of Gastroenterology, Department of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia
- 2. Liver Disease Research Centre, King Saud University, Riyadh, Kingdom of Saudi Arabia
- 3. Department of Infection and Immunity, Research Center, King Faisal Specialist Hospital and Research Center, P.O. Box 3354 (MBC-03), Riyadh, 11211, Kingdom of Saudi Arabia
- 4. Department of Tropical Medicine and Gastroenterology, Faculty of Medicine, Assiut University Hospitals, Assiut, Egypt
- 5. Department of Hepatobiliary Sciences and Liver Transplantation, King Abdulaziz Medical City, Riyadh, Kingdom of Saudi Arabia
- 6. Department of Medicine, King Faisal Specialist Hospital and Research Center, Riyadh, Kingdom of Saudi Arabia
- 7. Department of Gastroenterology, Riyadh Military Hospital, Riyadh, Kingdom of Saudi Arabia