Hepatology International

, Volume 7, Issue 1, pp 171–179

Association of IL28B genotypes with metabolic profiles and viral clearance rate in chronic hepatitis C patients

  • Ching-Sheng Hsu
  • Shih-Jer Hsu
  • Hung-Chia Chen
  • Chen-Hua Liu
  • Jenher Jeng
  • Chun-Jen Liu
  • Pei-Jer Chen
  • Ding-Shinn Chen
  • Jia-Horng Kao
Original Article

DOI: 10.1007/s12072-012-9390-3

Cite this article as:
Hsu, CS., Hsu, SJ., Chen, HC. et al. Hepatol Int (2013) 7: 171. doi:10.1007/s12072-012-9390-3

Abstract

Purpose

IL28B genotypes have a strong impact on treatment outcomes of chronic hepatitis C (CHC) and on-treatment viral kinetics. Since metabolic regulation and interferon response are highly integrated, metabolic profiles may play an important role in the link between IL28B genotypes and hepatitis C virus (HCV) infection. Thus, the association of IL28B rs8099917 genotypes with metabolic profiles and the impact of metabolic profiles on hepatitis C viral kinetic parameters were examined.

Methods

A case–control analysis including 278 CHC patients and 280 subjects without chronic HCV infection was performed. The associations of IL28B rs8099917 genotype with pretreatment metabolic profiles and early viral kinetic parameters were evaluated.

Results

Compared to HCV genotype 1 patients, the differences in metabolic profiles were more significant in genotype 2 patients. HCV genotype 2 patients with TT genotype had higher serum total cholesterol and high density lipoprotein (HDL) levels than those with GT genotype, and the differences remained significant when adjusted for age, sex, and body mass index (p = 0.005 for total cholesterol; p = 0.006 for HDL). In addition, patients with higher serum TG, higher fasting blood glucose, and lower HDL had a lower viral clearance rate.

Conclusions

IL28B genotypes may affect lipid profiles of CHC patients, especially in HCV-genotype 2 patients. Patients with higher serum fasting blood glucose, triglyceride, and lower HDL have a lower viral clearance rate during pegylated interferon plus ribavirin therapy.

Keywords

HCV RNA Hepatitis C virus IL28B genotype Mathematical model Metabolic profiles Pegylated interferon Viral kinetics 

Abbreviations

HCV

Hepatitis C virus

CHC

Chronic hepatitis C

Peg-IFN

Pegylated interferon

ALT

Alanine aminotransferase

GGT

Gamma-glutamyl transpeptidase

WBC

White blood count

PLT

Platelet count

BMI

Body mass index

ULN

Upper limit of normal

RVR

Rapid virologic response

EVR

Early virologic response

SVR

Sustained virologic response

SNP

Single nucleotide polymorphism

TG

Triglyceride

TC

Total cholesterol

HDL

High density lipoprotein

LDL

Low density lipoprotein

IR

Insulin resistance

Supplementary material

12072_2012_9390_MOESM1_ESM.doc (69 kb)
Supplementary material 1 (DOC 69 kb)

Copyright information

© Asian Pacific Association for the Study of the Liver 2012

Authors and Affiliations

  • Ching-Sheng Hsu
    • 1
    • 2
  • Shih-Jer Hsu
    • 3
    • 4
  • Hung-Chia Chen
    • 5
  • Chen-Hua Liu
    • 3
    • 6
  • Jenher Jeng
    • 7
  • Chun-Jen Liu
    • 3
    • 6
  • Pei-Jer Chen
    • 3
    • 6
    • 9
  • Ding-Shinn Chen
    • 3
    • 6
  • Jia-Horng Kao
    • 3
    • 6
    • 8
    • 9
  1. 1.Division of Gastroenterology, Department of Internal MedicineBuddhist Tzu Chi General HospitalTaipeiTaiwan
  2. 2.School of MedicineTzu Chi UniversityHualienTaiwan
  3. 3.Graduate Institute of Clinical MedicineNational Taiwan University College of Medicine, National Taiwan University HospitalTaipeiTaiwan
  4. 4.Department of Internal MedicineNational Taiwan University HospitalYun-LinTaiwan
  5. 5.Division of Personalized Nutrition and MedicineNational Center for Toxicological Research, FDAJeffersonUSA
  6. 6.Department of Internal Medicine, National Taiwan University College of MedicineNational Taiwan University HospitalTaipeiTaiwan
  7. 7.Center of Mathematical Modeling and Scientific ComputingNational Chiao Tung UniversityHsinchuTaiwan
  8. 8.Department of Medical Research, National Taiwan University College of MedicineNational Taiwan University HospitalTaipeiTaiwan
  9. 9.Hepatitis Research Center, National Taiwan University College of MedicineNational Taiwan University HospitalTaipeiTaiwan

Personalised recommendations