, Volume 6, Issue 2, pp 436-440
Date: 14 Jan 2012

The long way toward understanding host and viral determinants of therapeutic success in HCV infection

This is an excerpt from the content

The T helper type 1 (Th1)/Th2 hypothesis of immune regulation arose in the late 1980s, stemming from observations in mice [1]. Since then, the Th1/Th2 cytokine balance has been extensively described in humans as a pivotal component of antiviral immunity and pathogenesis in infections. In a simplistic view of the literature, Th1 cells are commonly associated with interferon-gamma (IFN-γ), interleukin (IL)-2 and IL-12 secretion, and these cells are hypothesized to mediate the response against intracellular pathogens such as viruses. Inversely, Th2 cells, which are most heavily reliant on IL-4, IL-5, IL-10 and IL-13, are supposed to emphasize protection against extracellular pathogens. In its modern incarnation, the role played by the Th1/Th2 balance in the regulation of cellular immunity against infections seems vaster and influenced by a large number of natural variables [2, 3]. In addition, since 1986 and the emergence of the Th1/Th2 hypothesis, other T-cell subpopulations, such as Th1 ...