Hepatology International

, Volume 5, Issue 3, pp 857–863

Coffee prevents CCl4-induced liver cirrhosis in the rat

  • Mario G. Moreno
  • Enrique Chávez
  • Liseth R. Aldaba-Muruato
  • José Segovia
  • Paula Vergara
  • Víctor Tsutsumi
  • Mineko Shibayama
  • Yadira Rivera-Espinoza
  • Pablo Muriel
Original Article

DOI: 10.1007/s12072-010-9247-6

Cite this article as:
Moreno, M.G., Chávez, E., Aldaba-Muruato, L.R. et al. Hepatol Int (2011) 5: 857. doi:10.1007/s12072-010-9247-6

Abstract

Purpose

Previous clinical observations suggested that coffee may have beneficial effects on the liver. In fact, an inverse relationship between coffee consumption and liver cirrhosis has been reported in humans. However, the causative role of coffee has not been established; therefore, the aim of this work was to study the effect of coffee in an experimental model of liver damage.

Methods

In this work, cirrhosis was induced by chronic CCl4 administration and soluble or grain coffee (SC, GC, respectively) were co-administered for 8 weeks.

Results

CCl4 administration elevated serum alkaline phosphatase and alanine aminotranspherase, liver lipid peroxidation, collagen content (fourfold) and TGF-β mRNA, and protein levels; depleted liver glycogen and reduced glutathione (GSH) content. Coffee prevented most of the changes produced by CCl4. Histopathological analysis was in agreement with biochemical and molecular data. The best effect was produced by GC. It is worth noting that GC preserved the normal collagen content as well as the normal TGF-β mRNA and protein levels.

Conclusions

Our results suggest (1) that coffee plays a causative role in preventing cirrhosis (at least experimental cirrhosis); (2) that action mechanisms are probably associated with down regulation of the profibrogenic cytokine TGF-β and to its antioxidant properties and, (3) that GC is more potent than SC. These findings suggest a beneficial effect of coffee on the liver. However, more clinical and basic studies must be performed before reaching a final recommendation.

Keywords

Antioxidants Carbon tetrachloride Cirrhosis Coffee Cytokines Fibrosis Liver damage TGF-β 

Copyright information

© Asian Pacific Association for the Study of the Liver 2011

Authors and Affiliations

  • Mario G. Moreno
    • 1
  • Enrique Chávez
    • 1
  • Liseth R. Aldaba-Muruato
    • 1
  • José Segovia
    • 2
  • Paula Vergara
    • 2
  • Víctor Tsutsumi
    • 3
  • Mineko Shibayama
    • 3
  • Yadira Rivera-Espinoza
    • 4
  • Pablo Muriel
    • 1
  1. 1.Departamento de FarmacologíaCinvestav-IPNMéxicoMéxico
  2. 2.Departamento de Fisiología Biofísica y NeurocienciasCinvestav-IPNMéxicoMéxico
  3. 3.Departamento de Infectómica y Patogénesis MolecularCinvestav-IPNMéxicoMéxico
  4. 4.Departamento de Graduados e Investigación en Alimentos, Escuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalMéxicoMéxico