Hepatology International

, Volume 5, Issue 2, pp 671–676

De novo combination of lamivudine and adefovir versus entecavir monotherapy for the treatment of naïve HBeAg-negative chronic hepatitis B patients

  • Li-Chun Wang
  • En-Qiang Chen
  • Jing Cao
  • Li Liu
  • Li Zheng
  • Da-Jiang Li
  • Lu Xu
  • Xue-Zhong Lei
  • Cong liu
  • Hong Tang
Original Article

DOI: 10.1007/s12072-010-9243-x

Cite this article as:
Wang, LC., Chen, EQ., Cao, J. et al. Hepatol Int (2011) 5: 671. doi:10.1007/s12072-010-9243-x

Abstract

Purpose

Either combination treatment or monotherapy using agents with a high genetic barrier are recommended for hepatitis B e antigen (HBeAg)-negative chronic hepatitis B (CHB). The aim of this study was to compare effect of naïve HBeAg-negative CHB patients with either de novo combination of lamivudine (LAM) and adefovir dipivoxil (ADV) or entecavir (ETV) monotherapy.

Methods

HBeAg-negative CHB patients (n = 71) with ALT levels between 2 and 10 times the upper normal limit and HBV DNA levels >104 copies/mL were enrolled. Patients were treated with either LAM 100 mg plus ADV 10 mg per day (n = 31) or ETV 0.5 mg per day (n = 40) for 48 weeks.

Results

The average reduction in HBV DNA level compared with baseline were 5.16 ± 1.69 log in the LAM + ADV group and 5.36 ± 1.70 log in the ETV group by week 48 (P = 0.624). The virological response (VR) rates were 80.65 and 77.5%, the biochemical response (BR) rates were 93.55 and 90.00% at week 48 in the LAM + ADV and ETV groups, respectively. There was no significant difference in the VR and BR between the two groups. During the 48-week treatment period, virological breakthrough and serious side effects were not noted in any patient.

Conclusions

Both LAM + ADV combination therapy and ETV monotherapy are effective in naïve HBeAg-negative CHB patients, but further studies are needed to obtain long-term results.

Keywords

Chronic hepatitis BHBeAg-negativeLamivudineAdefovir dipivoxilCombination treatmentEntecavirMonotherapy

Copyright information

© Asian Pacific Association for the Study of the Liver 2011

Authors and Affiliations

  • Li-Chun Wang
    • 1
    • 2
  • En-Qiang Chen
    • 1
    • 2
  • Jing Cao
    • 3
  • Li Liu
    • 1
    • 2
  • Li Zheng
    • 1
  • Da-Jiang Li
    • 1
  • Lu Xu
    • 1
    • 2
  • Xue-Zhong Lei
    • 1
    • 2
  • Cong liu
    • 1
    • 2
  • Hong Tang
    • 1
    • 2
  1. 1.Centre of Infectious Diseases, West China HospitalSichuan UniversityChengduChina
  2. 2.Division of Infectious Diseases, State Key Laboratory of BiotherapySichuan UniversityChengduChina
  3. 3.Information Centre, Sichuan Provincial Hospital for Women and ChildrenChengduChina