Hepatology International

, Volume 3, Issue 2, pp 364–370

High serum adiponectin correlates with advanced liver disease in patients with chronic hepatitis B virus infection

  • Chun-Jen Liu
  • Pei-Jer Chen
  • Ming-Yang Lai
  • Chen-Hua Liu
  • Chi-Lin Chen
  • Jia-Horng Kao
  • Ding-Shinn Chen
Original Article

DOI: 10.1007/s12072-008-9111-0

Cite this article as:
Liu, CJ., Chen, PJ., Lai, MY. et al. Hepatol Int (2009) 3: 364. doi:10.1007/s12072-008-9111-0

Abstract

Purpose

Adiponectin possesses anti-inflammatory and insulin-sensitizing properties. Little is known about the role of adiponectin in hepatitis B-related liver disease.

Methods

Serum adiponectin and hepatitis B viral factors were cross-sectionally assayed in 280 patients with chronic hepatitis B virus (HBV) infection including 120 patients with chronic HBV infection, 40 patients with cirrhosis, and 120 patients with hepatocellular carcinoma (HCC); 116 healthy adults were used as controls. The dynamics of serum adiponectin level was also studied longitudinally in 25 patients with hepatitis B e antigen (HBeAg) seroconversion (SC).

Results

We found that serum adiponectin level in patients with chronic HBV infection was similar to that in healthy controls and was significantly lower than patients with cirrhosis and HCC. In univariate analysis, high serum adiponectin level significantly correlated with the presence of HBV-related cirrhosis or HCC, abnormal serum ALT level, and HBV genotype C. Multivariate analysis revealed that high serum adiponectin level significantly correlated with the development of HCC. Serum adiponectin levels remained stationary in patients experiencing HBeAg SC.

Conclusions

Our findings suggest that HBV infection itself does not affect adiponectin levels. Serum adiponectin level correlates with the progression of HBV-related liver diseases but not with the development of HBeAg SC.

Keywords

Hepatitis B virus Adiponectin ALT HBeAg seroconversion Genotype 

Copyright information

© Asian Pacific Association for the Study of the Liver 2008

Authors and Affiliations

  • Chun-Jen Liu
    • 1
    • 2
    • 3
  • Pei-Jer Chen
    • 1
    • 2
    • 3
  • Ming-Yang Lai
    • 1
    • 2
  • Chen-Hua Liu
    • 2
  • Chi-Lin Chen
    • 1
  • Jia-Horng Kao
    • 1
    • 2
    • 3
    • 4
  • Ding-Shinn Chen
    • 1
    • 2
  1. 1.Graduate Institute of Clinical MedicineNational Taiwan University College of Medicine, National Taiwan University HospitalTaipeiTaiwan
  2. 2.Department of Internal MedicineNational Taiwan University College of Medicine, National Taiwan University HospitalTaipeiTaiwan
  3. 3.Department of Medical ResearchNational Taiwan University College of Medicine, National Taiwan University HospitalTaipeiTaiwan
  4. 4.Hepatitis Research CenterNational Taiwan University College of Medicine, National Taiwan University HospitalTaipeiTaiwan

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