Hepatology International

, Volume 2, Issue 4, pp 465–470

A 7-day profile of oxidative stress and antioxidant status in patients with acute liver failure

  • Vikram Bhatia
  • Payal Bhardwaj
  • Jessina Elikkottil
  • Jyoti Batra
  • Anoop Saraya
Original Article

DOI: 10.1007/s12072-008-9098-6

Cite this article as:
Bhatia, V., Bhardwaj, P., Elikkottil, J. et al. Hepatol Int (2008) 2: 465. doi:10.1007/s12072-008-9098-6

Abstract

Purpose

Acute liver failure (ALF) is characterized by a rapid and massive destruction of hepatocytes. The role of oxidative stress in perpetuating the injury is undefined and may be a potential therapeutic target. Our aim was to study serial variation in oxidative stress and antioxidant status in patients with ALF.

Methods

The study involved a prospective case–control study set in a tertiary care referral center. Thirty-two consecutive patients admitted with ALF were included with 23 healthy controls for comparison. Level of systemic oxidative stress as defined by superoxide dismutase (SOD), lipid peroxidation products (thiobarbituric acid reactive derivatives [TBARS]), and the total antioxidant capacity as the ferric reducing ability of plasma (FRAP) was measured at baseline on days 3 and 7.

Results

The patients were aged 24 years (range 13–60 years) and included 20 females. Thirteen (40.6%) patients died. Patients with ALF had significantly increased systemic oxidative stress at presentation, as reflected by higher levels of SOD (P < 0.001) and TBARS (P < 0.001) than controls. Both TBARS levels and FRAP decreased progressively from admission to the end of first week among the survivors (P = 0.004 and 0.015, respectively). The antioxidant status reflected by FRAP (P = 0.001) was significantly lower in ALF patients than controls. No relation was found between the level of oxidative stress and the mortality or complications.

Conclusion

A high level of systemic oxidative stress exists in ALF, with depletion of antioxidant reserves. Further studies are needed to define the clinical correlation of the large pro-oxidant burden.

Keywords

Acute liver failure Oxidative stress Antioxidant status profile 

Copyright information

© Asian Pacific Association for the Study of the Liver 2008

Authors and Affiliations

  • Vikram Bhatia
    • 1
  • Payal Bhardwaj
    • 1
  • Jessina Elikkottil
    • 1
  • Jyoti Batra
    • 1
  • Anoop Saraya
    • 1
  1. 1.Department of Gastroenterology and Human NutritionAll India Institute of Medical SciencesNew DelhiIndia

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