Invited Article

Indian Journal of Otolaryngology and Head & Neck Surgery

, Volume 65, Supplement 3, pp 650-653

First online:

Intratympanic Dexamethasone on Cochlear Blood Flow in Guinea Pigs

  • Rayleigh Ping-Ying ChiangAffiliated withDepartment of Otolaryngology Head and Neck Surgery, School of Medicine, Fu Jen Catholic UniversityDepartment of Otolaryngology Head and Neck Surgery, Shin Kong Wu Ho-Su Memorial HospitalSleep Technology Special Interest Group, Center of Innovation and Synergy for Intelligent Home Technology, National Taiwan University
  • , Ching-Ying YehAffiliated withSchool of Public Health, Taipei Medical University Taiwan
  • , Yuh-Chyun ChiangAffiliated withDepartment of Otolaryngology, Taiwan Adventist HospitalDepartment of Otolaryngology, School of Medicine, Taipei Medical University
  • , Kai-Nan LinAffiliated withDepartment of Otolaryngology Head and Neck Surgery, Cardinal Tien HospitalDepartment of Otolaryngology Head and Neck Surgery, National Taiwan University Hospital Email author 

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To determine the effect of intratympanically delivered dexamethasone on cochlear blood flow. 29 white Hartly guinea pigs were divided into 2 groups. By laser Doppler flowmeter, baseline data were recorded in the first 15–20 min, followed by 20 min’ recording after applying dexamethasone or normal saline, with a record of flow every 5 min in 2 groups. Friedman Test was used to test the change of blood flow in these four timing. There were no significant changes of blood flow after injecting dexamethasone (p = .18 > .05) and normal saline (p = .93 > .05). The effects of dexamethasone on cochlear blood flow were variable and not significant. The following research would be designed under pathological conditions, such as cochlear ischemia, to show the possible mechanism of dexamethasone for specific inner ear disease. Level of evidence: 3a (SR of case–control studies).


Steroids Microcirculation Round window Laser Doppler flowmeter