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Synthesis and bio-catalytic activity of isostructural cobalt(III)-phenanthroline complexes

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We have synthesized two isostructural mononuclear cobalt(III) complexes [1]NO3⋅3H2O and [1]NO3⋅CH3CO2H⋅H2O {[1] + = [Co(1,10-phenanthroline)2Cl2]+} and characterized by single crystal X-ray structural analyses. Mass spectral studies of the complexes indicate both the compounds to produce identical cationic species viz., [Co(phen)2Cl2]+ in methanol solution. [1]+ has been evaluated as model system for the catechol oxidase enzyme by using 3,5-di-tert-butylcatechol (3,5-DTBC) as the substrate in methanol medium, which revealed that the cationic complex efficiently inhibits catalytic activity with kcat value 9.65 ×102 h−1. [1]+ cleaved pBR 322 DNA without addition of an activating agent. Further, the anti-cancer activity of [1]+ on human hepatocarcinoma cell line (HepG2) has been examined. The induction of apoptosis induced in the cell line was assessed base on the changes in cell morphology, which showed the efficacy of [1] + to induce apoptosis in 53% of cells during 24 h treatment. Interestingly, the observed IC50 values reveal that [1]+ brings about conformational change on DNA strongly and exhibits remarkable cytotoxicity.

The cationic cobalt(III) complex exhibits good catalytic activity in saturated oxygen environment towards 3,5-ditertbutylcatechol with kcat value 9.65×102 h-1. It also exhibits important cytotoxicity against human hepatocarcinoma cell line (HepG2).

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Acknowledgements

The work was supported financially by the Department of Science and Technology (DST), New Delhi, India under FAST TRACK SCHEME for YOUNG SCIENTIST (NO. SB/FT/CS-088/2013 dtd. 21/05/2014). B. Biswas also gratefully acknowledges the financial support from the University Grant Commission, New Delhi, India (F. No. PSW-84/12-13(ERO) dated 05/02/2013). B. Biswas is highly thankful to IACS, Kolkata for facilitating proton NMR and mass spectrometric studies.

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  1. SARAVANAN CHANDRALEKA

    Present address: Department of Chemistry, Urumu Dhanalakshmi College, Tiruchirappalli, 620019, India

Authors and Affiliations

  1. Department of Chemistry, Raghunathpur College, Purulia, 723133, India

    DHANANJAY DEY, ARNAB BASU ROY, NIRANJAN KOLE & BHASKAR BISWAS

  2. Department of Microbiology, Bharathidasan University, Tiruchirappalli, 620 024, India

    ANANDAN RANJANI, LOGANATHAN GAYATHRI, SARAVANAN CHANDRALEKA & DHARUMADURAI DHANASEKARAN

  3. Mahatma Gandhi-Doerenkamp Centre, Bharathidasan University, Tiruchirappalli, 620 024, India

    MOHAMMAD ABDULKADER AKBARSHA

  4. Department of Chemistry, National Cheng Kung University, Tainan City, 70101, Taiwan

    CHUNG-YU SHEN & HUI-LIEN TSAI

  5. Department of Chemistry, National Institute of Technology, Mahatma Gandhi Avenue, Durgapur, 713209, India

    MILAN MAJI

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Supplementary Information

Crystallographic data are available free of charge from The Director, CCDC, 12 Union Road, Cambridge, CB2 1EZ, UK (fax: +44-1223-336033; E-mail: deposit@ccdc.cam.ac.uk or www: http://www.ccdc.cam.ac.uk) upon request, quoting deposition number CCDC 829003 for [1]NO3⋅3H2O and and CCDC 975400 for [1]NO3⋅CH3CO2H⋅H2O. Figures S1-S9 and tables S1-S3 are available in the online version at www.ias.ac.in/chemsci.

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DEY, D., ROY, A.B., RANJANI, A. et al. Synthesis and bio-catalytic activity of isostructural cobalt(III)-phenanthroline complexes. J Chem Sci 127, 649–661 (2015). https://doi.org/10.1007/s12039-015-0817-y

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