Journal of Chemical Sciences

, Volume 121, Issue 4, pp 485–495

Synthesis of some new 4-aryloxmethylcoumarins and examination of their antibacterial and antifungal activities

Authors

  • Mahantesha Basanagouda
    • Post-Graduate Department of ChemistryKarnatak University
    • Post-Graduate Department of ChemistryKarnatak University
  • Deepak Sharma
    • Post-Graduate Department of PhysicsUniversity of Jammu
  • Vivek K. Gupta
    • Post-Graduate Department of PhysicsUniversity of Jammu
  • Pranesha
    • Department of PharmacologyKLE’s College of Pharmacy
  • P. Sandhyarani
    • Department of PharmacologyKLE’s College of Pharmacy
  • Vijaykumar P. Rasal
    • Department of PharmacologyKLE’s College of Pharmacy
Article

DOI: 10.1007/s12039-009-0058-z

Cite this article as:
Basanagouda, M., Kulkarni, M.V., Sharma, D. et al. J Chem Sci (2009) 121: 485. doi:10.1007/s12039-009-0058-z

Abstract

A number of new 4-aryloxymethylcoumarins 3 and 5 have been obtained from the reaction of various 4-bromomethylcoumarins with 2-nitro-p-cresol 2 and 2,6-dibromo-p-cresol 4. NOE studies have been carried out on two compounds to ascertain their spatial proximity. p-cresol ethers 7 have been subjected to bromination in chloroform and the position of bromine has been established by diffraction studies. Cleavage of the ether linkage has been observed during an attempted nitration of ethers 7. Antimicrobial activity of all the compounds against five bacterial and five fungal species have been reported.

Keywords

4-BromomethylcoumarinsNOEX-rayelectrophilic substitutionfluorescentantimicrobial

Copyright information

© Indian Academy of Sciences 2009