Journal of Biosciences

, Volume 36, Issue 4, pp 731–737

Animal models for the study of arterial hypertension

Authors

  • Waleska C Dornas
    • Research in Biological Sciences - NUPEBOuro Preto University
    • Department of Foods, School of NutritionOuro Preto University
Review

DOI: 10.1007/s12038-011-9097-y

Cite this article as:
Dornas, W.C. & Silva, M.E. J Biosci (2011) 36: 731. doi:10.1007/s12038-011-9097-y

Abstract

Hypertension is one of the leading causes of disability or death due to stroke, heart attack and kidney failure. Because the etiology of essential hypertension is not known and may be multifactorial, the use of experimental animal models has provided valuable information regarding many aspects of the disease, which include etiology, pathophysiology, complications and treatment. The models of hypertension are various, and in this review, we provide a brief overview of the most widely used animal models, their features and their importance.

Keywords

Blood pressurecardiovascular diseaseexperimental modelshypertension

Abbreviations used:

ANG II

angiotensin II

BHR

borderline hypertensive rat

CBF

cerebral blood flow

DOCA

11-desoxycorticosterone acetate

DR

Dahl salt-resistant rat

DS

Dahl salt-sensitive rat

EDCF

endothelium-derived constricting factor

EDRF

endothelium-derived relaxing factor

HR

heart rate

LV

left ventricle

MAP

mean arterial pressure

PRA

plasma rennin activity

RAAS

rennin–angiotensin–aldosterone system

ROS

reactive oxygen species

RSNA

renal sympathetic nerve activity

SAD

sinoaortic baroreceptors

SHR

spontaneously hypertensive rat

SHRSP

stroke-prone spontaneously hypertensive rat

SOD

superoxide dismutase

WKY

Wistar–Kyoto

Copyright information

© Indian Academy of Sciences 2011