Human pancreatic islet progenitor cells demonstrate phenotypic plasticity in vitro
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- Dalvi, M.P., Umrani, M.R., Joglekar, M.V. et al. J Biosci (2009) 34: 523. doi:10.1007/s12038-009-0071-x
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Phenotypic plasticity is a phenomenon that describes the occurrence of 2 or more distinct phenotypes under diverse conditions. This article discusses the work carried out over the past few years in understanding the potential of human pancreatic islet-derived progenitors for cell replacement therapy in diabetes. The phenotypic plasticity exhibited by pancreatic progenitors during reversible epithelial-to-mesenchymal transition (EMT) and possible role of microRNAs in regulation of this process is also presented herein.