, Volume 34, Issue 4, pp 523-528
Date: 24 Apr 2009

Human pancreatic islet progenitor cells demonstrate phenotypic plasticity in vitro

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Phenotypic plasticity is a phenomenon that describes the occurrence of 2 or more distinct phenotypes under diverse conditions. This article discusses the work carried out over the past few years in understanding the potential of human pancreatic islet-derived progenitors for cell replacement therapy in diabetes. The phenotypic plasticity exhibited by pancreatic progenitors during reversible epithelial-to-mesenchymal transition (EMT) and possible role of microRNAs in regulation of this process is also presented herein.

Supplementary movies 1 and 2 pertaining to this article are available on the Journal of Biosciences Website at http://www.ias.ac.in/jbiosci/Oct2009/pp523–528.suppl.pdf