Journal of Biosciences

, Volume 32, Supplement 2, pp 1207–1212

Sphingosine 1-phosphate as a novel immune regulator of dendritic cells

Review

DOI: 10.1007/s12038-007-0122-0

Cite this article as:
Martino, A. J Biosci (2007) 32(Suppl 2): 1207. doi:10.1007/s12038-007-0122-0

Abstract

Although originally described as an intracellular second messenger, sphingosine 1-phosphate (S1P) has recently been shown to be involved in several physiological and pathological functions as an extracellular mediator. S1P receptors are widely expressed and thought to regulate important functions in cell signalling. Recently, the role of S1P on the immune system has evoked great interest. In particular, several aspects of the effects on antigen-presenting cells (APCs) as dendritic cells (DC) in mice and humans have been reported. In this review, we focus on the role played by S1P on the DC system and its effects in immune-related pathological states.

Keywords

Cell differentiation dendritic cells immunity lipids sphingosine 1-phosphate 

Abbreviations used

APC

antigen-presenting cells

DC

dendritic cells

GM-CSF

granulocyte-macrophage colony-stimulating factor

GPCR

G protein-coupled receptors

GTP

guanosine triphosphate

IFN

interferon

IL

interleukin

imDC

immature DC

LPA

lysophosphatidic acid

LPS

lipopolysaccharides

mDC

mature DC

MHC

major histocompatibility complex

NK

natural killer

PCR

polymerase chain reaction

RANTES

regulated on activation normal T cell expressed and secreted

S1P

sphingosine 1-phosphate

TNF

tumour necrosis factor

Copyright information

© Indian Academy of Sciences 2007

Authors and Affiliations

  1. 1.Unit of Cellular Immunology, National Institute for Infectious DiseasesIRCCS ‘Lazzaro Spallanzani’RomeItaly

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