Abstract
The differential sensitivity of neurons to phosphatase and tensin homolog’s (PTEN) lipid and protein phosphatase actions pose difficulties in defining the exact neuronal phenotype generated by targeting PTEN in neuronal injury. PTEN’s biology beyond its phosphatase functions are also emerging. Considering spatial dynamics of PTEN a decisive factor for its mode of action we propose selective targeting of its cytoplasmic fraction a better therapeutic approach in neuronal injury.
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Acknowledgments
AK is supported by a Alberta Innovates-Health Solutions (AI-HS) postdoctoral fellowship. The Zochodne laboratory is supported by operating grants from the Canadian Institutes of Health Research (CIHR), the National Institutes of Health (NIH, Diabetes Complications Consortium), and Canadian Diabetes Association.
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The authors declare no competing financial interests.
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Krishnan, A., Zochodne, D.W. Is Cytoplasmic PTEN a Specific Target for Neuronal Survival?. Mol Neurobiol 52, 1758–1764 (2015). https://doi.org/10.1007/s12035-014-8922-3
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DOI: https://doi.org/10.1007/s12035-014-8922-3