Molecular Neurobiology

, Volume 48, Issue 2, pp 302–307

Utilization of Neural Stem Cell-Derived Models to Study Anesthesia-Related Toxicity and Preventative Approaches

  • Cheng Wang
  • Fang Liu
  • Tucker A. Patterson
  • Merle G. Paule
  • William SlikkerJr.
Article

DOI: 10.1007/s12035-013-8501-z

Cite this article as:
Wang, C., Liu, F., Patterson, T.A. et al. Mol Neurobiol (2013) 48: 302. doi:10.1007/s12035-013-8501-z

Abstract

Early-life stress has been shown in both preclinical and clinical studies to cause neuroanatomical and biological alterations and disruptions in homeostasis. These alterations can lead to dysfunction in critical regulatory systems and concomitant increases in risk for the development of pathology. The existing data from research using in vivo animal models have implicated some general anesthetics as being toxic to the developing brain and causing cognitive deficits later in life. Because of obvious limitations, it is not possible to thoroughly explore the effects of early-life stress—e.g., prolonged exposure to anesthetic agents—on neurons in vivo in human infants or children. However, the availability of stem cell-derived models, especially human embryonic neural stem cells, along with their capacity for proliferation and ability to differentiate, has provided a potentially invaluable tool for examining the developmental effects of anesthetic agents in vitro. This review focuses on how embryonic neural stem cells, when combined with biochemical, pathological, and pharmacokinetic assessments, might serve as a bridging platform to provide the most expeditious approaches toward decreasing the uncertainty in extrapolating preclinical data to the human condition. This review presents key concepts in stem cell biology with respect to the nervous system, presents an overview of neural development, and summarizes the involvement of neural cell types in developmental neurotoxicity associated with anesthetic exposure.

Keywords

Neural stem cellsDevelopmentAnesthesiaToxicologyNeuroprotection

Copyright information

© Springer Science+Business Media New York (outside the USA) 2013

Authors and Affiliations

  • Cheng Wang
    • 1
    • 3
  • Fang Liu
    • 1
  • Tucker A. Patterson
    • 1
  • Merle G. Paule
    • 1
  • William SlikkerJr.
    • 2
  1. 1.Division of NeurotoxicologyNational Center for Toxicological Research (NCTR)/FDAJeffersonUSA
  2. 2.Office of the DirectorNational Center for Toxicological Research (NCTR)/FDAJeffersonUSA
  3. 3.National Center for Toxicological Research, HFT-132Food and Drug AdministrationJeffersonUSA