Molecular Neurobiology

, Volume 46, Issue 1, pp 221–226

Neuroinflammation and Proteostasis are Modulated by Endogenously Biosynthesized Neuroprotectin D1

Article

DOI: 10.1007/s12035-012-8322-5

Cite this article as:
Bazan, N.G. Mol Neurobiol (2012) 46: 221. doi:10.1007/s12035-012-8322-5

Abstract

Neurodegenerative diseases encompass complex cell signaling disturbances that initially damage neuronal circuits and synapses. Due to multiple protective mechanisms enacted to counteract the onset of neurodegenerative diseases, there is often a prolonged period without noticeable impairments during their initiation. Since severe cognitive deficit or vision loss takes place after that period there is an opportunity to harness endogenous protective mechanisms as potential therapeutic approaches. The activation of the biosynthesis of the docosanoid mediator neuroprotectin D1 (NPD1) is an early response to the upsurge of protein misfolding and other neuroinflammatory events. This overview discusses the potent neuroprotective and inflammation-modulating bioactivity of NPD1. This lipid mediator represents an early response to neurodegenerations, aiming to restore homeostasis.

Keywords

MisfoldingRetinal degenerationsAlzheimer’s diseaseHuntington’s diseaseEpilepsyDocosahexaenoic acidAtaxin-1HuntingtinCAG repeatsAPPBcl-2 proteins

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Neuroscience Center of ExcellenceLouisiana State University Health Sciences CenterNew OrleansUSA