Article

Molecular Neurobiology

, Volume 45, Issue 3, pp 605-620

Role of Dopamine Receptors in ADHD: A Systematic Meta-analysis

  • Jing WuAffiliated withDepartment of Epidemiology and Biostatistics and Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology
  • , Haifan XiaoAffiliated withDepartment of Epidemiology and Biostatistics and Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology
  • , Hongjuan SunAffiliated withDepartment of Epidemiology and Biostatistics and Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology
  • , Li ZouAffiliated withDepartment of Epidemiology and Biostatistics and Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology
  • , Ling-Qiang ZhuAffiliated withDepartment of Pathophysiology and Key Lab of Neurological Disease of Education Ministry, Tongji Medical College, Huazhong University of Science and Technology Email author 

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Abstract

The dopaminergic system plays a pivotal role in the central nervous system via its five diverse receptors (D1–D5). Dysfunction of dopaminergic system is implicated in many neuropsychological diseases, including attention deficit hyperactivity disorder (ADHD), a common mental disorder that prevalent in childhood. Understanding the relationship of five different dopamine (DA) receptors with ADHD will help us to elucidate different roles of these receptors and to develop therapeutic approaches of ADHD. This review summarized the ongoing research of DA receptor genes in ADHD pathogenesis and gathered the past published data with meta-analysis and revealed the high risk of DRD5, DRD2, and DRD4 polymorphisms in ADHD.

Keywords

ADHD Dopamine receptor Meta-analysis