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Role of Dopamine Receptors in ADHD: A Systematic Meta-analysis

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Abstract

The dopaminergic system plays a pivotal role in the central nervous system via its five diverse receptors (D1–D5). Dysfunction of dopaminergic system is implicated in many neuropsychological diseases, including attention deficit hyperactivity disorder (ADHD), a common mental disorder that prevalent in childhood. Understanding the relationship of five different dopamine (DA) receptors with ADHD will help us to elucidate different roles of these receptors and to develop therapeutic approaches of ADHD. This review summarized the ongoing research of DA receptor genes in ADHD pathogenesis and gathered the past published data with meta-analysis and revealed the high risk of DRD5, DRD2, and DRD4 polymorphisms in ADHD.

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Acknowledgments

The manuscript is supported by the National Nature Science Foundation of China (NSFC) (81101016), New Century Excellent Talents in University (NCET-10-0421), and the Ministry of Science and Technology of China (2011DFG33250).

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The authors declared no conflicts of interest.

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Authors and Affiliations

  1. Department of Epidemiology and Biostatistics and Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

    Jing Wu, Haifan Xiao, Hongjuan Sun & Li Zou

  2. Department of Pathophysiology and Key Lab of Neurological Disease of Education Ministry, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

    Ling-Qiang Zhu

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  1. Jing Wu
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  2. Haifan Xiao
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  3. Hongjuan Sun
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Correspondence to Ling-Qiang Zhu.

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Wu, J., Xiao, H., Sun, H. et al. Role of Dopamine Receptors in ADHD: A Systematic Meta-analysis. Mol Neurobiol 45, 605–620 (2012). https://doi.org/10.1007/s12035-012-8278-5

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