Molecular Neurobiology

, Volume 44, Issue 2, pp 192–201

Modulation of Nrf2/ARE Pathway by Food Polyphenols: A Nutritional Neuroprotective Strategy for Cognitive and Neurodegenerative Disorders

  • Giovanni Scapagnini
  • Vasto Sonya
  • Abraham G. Nader
  • Caruso Calogero
  • Davide Zella
  • Galvano Fabio
Article

DOI: 10.1007/s12035-011-8181-5

Cite this article as:
Scapagnini, G., Sonya, V., Nader, A.G. et al. Mol Neurobiol (2011) 44: 192. doi:10.1007/s12035-011-8181-5

Abstract

In recent years, there has been a growing interest, supported by a large number of experimental and epidemiological studies, for the beneficial effects of some phenolic substances, contained in commonly used spices and herbs, in preventing various age-related pathologic conditions, ranging from cancer to neurodegenerative diseases. Although the exact mechanisms by which polyphenols promote these effects remain to be elucidated, several reports have shown their ability to stimulate a general xenobiotic response in the target cells, activating multiple defense genes. Data from our and other laboratories have previously demonstrated that curcumin, the yellow pigment of curry, strongly induces heme-oxygenase-1 (HO-1) expression and activity in different brain cells via the activation of heterodimers of NF-E2-related factors 2 (Nrf2)/antioxidant responsive element (ARE) pathway. Many studies clearly demonstrate that activation ofNrf2 target genes, and particularly HO-1, in astrocytes and neurons is strongly protective against inflammation, oxidative damage, and cell death. In the central nervous system, the HO system has been reported to be very active, and its modulation seems to play a crucial role in the pathogenesis of neurodegenerative disorders. Recent and unpublished data from our group revealed that low concentrations of epigallocatechin-3-gallate, the major green tea catechin, induces HO-1 by ARE/Nrf2 pathway in hippocampal neurons, and by this induction, it is able to protect neurons against different models of oxidative damages. Furthermore, we have demonstrated that other phenolics, such as caffeic acid phenethyl ester and ethyl ferulate, are also able to protect neurons via HO-1 induction. These studies identify a novel class of compounds that could be used for therapeutic purposes as preventive agents against cognitive decline.

Keywords

Heterodimers of NF-E2-related factors 2 (Nrf2)Antioxidant responsive element (ARE)Heme oxygenase 1 (HO-1)Neurodegenerative disordersAlzheimer’s diseasePolyphenolsCurcumin(-)- epigallocatechin-3- gallate (EGCG)Brain ageing

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Giovanni Scapagnini
    • 1
  • Vasto Sonya
    • 2
  • Abraham G. Nader
    • 3
  • Caruso Calogero
    • 2
  • Davide Zella
    • 5
  • Galvano Fabio
    • 4
  1. 1.Department of Health SciencesUniversity of MoliseCampobassoItaly
  2. 2.Immunosenescence Unit, Department of Pathobiology and Biomedical MethodologiesUniversity of PalermoPalermoItaly
  3. 3.Department of Physiology and Pharmacology, College of MedicineUniversity of ToledoToledoUSA
  4. 4.Department of Biological Chemistry, Medical Chemistry and Molecular BiologyUniversity of CataniaCataniaItaly
  5. 5.Department of Biochemistry and Molecular Biology, Institute of Human Virology-School of MedicineUniversity of MarylandBaltimoreUSA