Molecular Neurobiology

, Volume 40, Issue 3, pp 260-288

Ionotropic Glutamate Receptors in Spinal Nociceptive Processing

  • Max LarssonAffiliated withDepartment of Anatomy and Centre for Molecular Biology and Neuroscience, University of Oslo Email author 

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Glutamate is the predominant excitatory transmitter used by primary afferent synapses and intrinsic neurons in the spinal cord dorsal horn. Accordingly, ionotropic glutamate receptors mediate basal spinal transmission of sensory, including nociceptive, information that is relayed to supraspinal centers. However, it has become gradually more evident that these receptors are also crucially involved in short- and long-term plasticity of spinal nociceptive transmission, and that such plasticity have an important role in the pain hypersensitivity that may result from tissue or nerve injury. This review will cover recent findings on pre- and postsynaptic regulation of synaptic function by ionotropic glutamate receptors in the dorsal horn and how such mechanisms contribute to acute and chronic pain.


Hyperalgesia Nociception AMPA receptors NMDA receptors Kainate receptors Long-term potentiation Presynaptic regulation Synaptic plasticity