Article

Molecular Neurobiology

, Volume 36, Issue 3, pp 232-244

Group I mGluRs and Long-Term Depression: Potential Roles in Addiction?

  • Brad A. GrueterAffiliated withDepartment of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine
  • , Zoé A. McElligottAffiliated withNeuroscience Graduate Program, Vanderbilt University School of Medicine
  • , Danny G. WinderAffiliated withDepartment of Molecular Physiology and Biophysics, Vanderbilt University School of MedicineNeuroscience Graduate Program, Vanderbilt University School of MedicineVanderbilt Brain Institute, Vanderbilt University School of Medicine Email author 

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Abstract

Addiction is an enormous societal problem. A number of recent studies have focused on adaptations at glutamatergic synapses that may play a role in the behavioral responses to drugs of abuse. These studies have largely focused on NMDA receptor-dependent forms of synaptic plasticity such as NMDA receptor-dependent long-term potentiation (LTP) and long-term depression (LTD). A growing body of evidence, however, suggests that metabotropic glutamate receptors (mGluRs) also play important roles in the behavioral responses to drugs of abuse and participate in producing synaptic plasticity at glutamate synapses. In this review, we focus first on the evidence supporting a role for mGluRs in addiction and then on the properties of mGluR-dependent forms of synaptic plasticity, focusing in particular on Gq-linked receptor-induced LTD.

Keywords

Addiction Group I mGluRs Long-term depression